774405
(S)-2-氨基丁烷-1,4-二硫醇 盐酸盐
99% (titration)
别名:
(S)-2-氨基丁烷-1,4-二硫醇 盐酸盐, (2S)-2-氨基-1,4-二巯基丁烷 盐酸盐, DTBA, 二硫代丁胺
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关于此项目
经验公式（希尔记法）:
C4H11NS2 · HCl
化学文摘社编号:
分子量:
173.73
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.22
方案
99% (titration)
表单
solid
反应适用性
reagent type: reductant
mp
210-225 °C
储存温度
2-8°C
SMILES字符串
Cl.N[C@H](CS)CCS
InChI
1S/C4H11NS2.ClH/c5-4(3-7)1-2-6;/h4,6-7H,1-3,5H2;1H/t4-;/m0./s1
InChI key
HWWPXJZINVJNBM-WCCKRBBISA-N
应用
二硫代丁胺或DTBA是一种新型生物还原剂，其性能优于其他常用试剂。DTBA被证明比DTT还原小分子二硫化物快3-5倍，并且与DTT相比，还原（激活）半胱氨酸依赖性蛋白酶木瓜蛋白酶的速度快14倍。另外，由于伯胺基的存在，使得从混合物中去除DTBA的过程变得更加简单，并且可以使用阳离子交换树脂来实现。
（S）-2-氨基丁烷-1,4-二硫醇盐酸盐（DTBA），也称为二硫代丁胺，是一种生物还原剂，具有比其他常用试剂更高的性能。 DTBA被证明比DTT还原小分子二硫化物快3-5倍，并且与DTT相比，还原（激活）半胱氨酸依赖性蛋白酶木瓜蛋白酶的速度快14倍。 另外，由于伯胺基的存在，使用后从混合物中去除DTBA的过程得到简化，并且可以使用阳离子交换树脂来实现。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Journal of the American Chemical Society, 134(9), 4057-4059 (2012)
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Inorganic chemistry, 58(5), 3290-3301 (2019-02-13)
Direct reactions under ambient conditions between CuX (X = Br, I) and thiobenzamide (TBA) were carried out at different ratios, giving rise to the formation of a series of one-dimensional (1D) coordination polymers, (CPs) [CuI(TBA)] n (1), [Cu3I3(TBA)2] n (4)
Coordination properties of dithiobutylamine (DTBA), a newly introduced protein disulfide reducing agent.
Adamczyk J, et al.
Inorganic Chemistry, 54(2), 596-606 (2014)
Sean B Johnston et al.
PloS one, 10(1), e0116898-e0116898 (2015-01-22)
Phosphatase and tensin homologue deleted from chromosome ten (PTEN) is a lipid phosphatase tumor suppressor that is lost or inactivated in most human tumors. The enzyme catalyzes the hydrolysis of phosphatidylinositol-(3,4,5)-trisphosphate (PIP3) to form phosphatidylinositol-(4,5)-bisphosphate (PIP2) and inorganic phosphate. Here
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