774405
(S)-2-氨基丁烷-1,4-二硫醇 盐酸盐
99% (titration)
别名:
(S)-2-氨基丁烷-1,4-二硫醇 盐酸盐, (2S)-2-氨基-1,4-二巯基丁烷 盐酸盐, DTBA, 二硫代丁胺
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关于此项目
经验公式（希尔记法）:
C4H11NS2 · HCl
化学文摘社编号:
分子量:
173.73
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.22
质量水平
方案
99% (titration)
表单
solid
反应适用性
reagent type: reductant
mp
210-225 °C
储存温度
2-8°C
SMILES字符串
Cl.N[C@H](CS)CCS
InChI
1S/C4H11NS2.ClH/c5-4(3-7)1-2-6;/h4,6-7H,1-3,5H2;1H/t4-;/m0./s1
InChI key
HWWPXJZINVJNBM-WCCKRBBISA-N
应用
二硫代丁胺或DTBA是一种新型生物还原剂，其性能优于其他常用试剂。DTBA被证明比DTT还原小分子二硫化物快3-5倍，并且与DTT相比，还原（激活）半胱氨酸依赖性蛋白酶木瓜蛋白酶的速度快14倍。另外，由于伯胺基的存在，使得从混合物中去除DTBA的过程变得更加简单，并且可以使用阳离子交换树脂来实现。
（S）-2-氨基丁烷-1,4-二硫醇盐酸盐（DTBA），也称为二硫代丁胺，是一种生物还原剂，具有比其他常用试剂更高的性能。 DTBA被证明比DTT还原小分子二硫化物快3-5倍，并且与DTT相比，还原（激活）半胱氨酸依赖性蛋白酶木瓜蛋白酶的速度快14倍。 另外，由于伯胺基的存在，使用后从混合物中去除DTBA的过程得到简化，并且可以使用阳离子交换树脂来实现。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Javier Troyano et al.
Inorganic chemistry, 58(5), 3290-3301 (2019-02-13)
Direct reactions under ambient conditions between CuX (X = Br, I) and thiobenzamide (TBA) were carried out at different ratios, giving rise to the formation of a series of one-dimensional (1D) coordination polymers, (CPs) [CuI(TBA)] n (1), [Cu3I3(TBA)2] n (4)
Mozhdeh Imaninezhad et al.
Bioconjugate chemistry, 30(1), 34-46 (2018-12-19)
Macroporous cell-laden hydrogels have recently gained recognition for a wide range of biomedical and bioengineering applications. There are various approaches to create porosity in hydrogels, including lyophilization or foam formation. However, many do not allow a precise control over pore
A potent, versatile disulfide-reducing agent from aspartic acid.
Lukesh III, et al.
Journal of the American Chemical Society, 134(9), 4057-4059 (2012)
Coordination properties of dithiobutylamine (DTBA), a newly introduced protein disulfide reducing agent.
Adamczyk J, et al.
Inorganic Chemistry, 54(2), 596-606 (2014)
Aiping Wen et al.
Materials science & engineering. C, Materials for biological applications, 111, 110759-110759 (2020-04-14)
Ovarian cancer is considered to be the most fatal reproductive cancers. Melphalan is used to treat ovarian cancer as an intraperitoneal chemotherapy agent. However, elucidating its pharmacokinetic behavior and preparing it for administration are challenging since it undergoes spontaneous hydrolysis.
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