InChI
1S/C2Cl2N4/c3-1-5-7-2(4)8-6-1
SMILES string
ClC1=NN=C(Cl)N=N1
InChI key
HXXFMIAFWKZHDY-UHFFFAOYSA-N
assay
96%
form
solid
availability
available only in USA
mp
146-151 °C
storage temp.
2-8°C
Quality Level
Application
据报道，试剂可作为光化学触剂发用于复杂肽的吻合。Amos Smith 教授及其同事在最近的几份报告中展示了这一应用。
Other Notes
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Self-react. C - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
5.2 - Organic peroxides and self-reacting hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Stephen P Brown et al.
Journal of the American Chemical Society, 137(12), 4034-4037 (2015-03-21)
Protocols have been achieved that permit facile introduction of s-tetrazine into unprotected peptides and the protein, thioredoxin, between two cysteine sulfhydryl groups (i.e., staple), followed by photochemical release (i.e., unstaple) and regeneration of the peptide/protein upon removal of the cyano
Joel R Courter et al.
The Journal of organic chemistry, 79(2), 759-768 (2013-12-24)
The design and synthesis of alanine-rich α-helical peptides constrained in a partially unfolded state by incorporation of the S,S-tetrazine phototrigger has been achieved, permitting, upon photochemical release, observation by 2D-IR spectroscopy of the subnanosecond conformational dynamics that govern the early
Mohannad Abdo et al.
Organic letters, 14(13), 3518-3521 (2012-06-27)
The design, solid-phase synthesis, and photochemical validation of diverse peptide linchpins, containing the S,S-tetrazine phototrigger, have been achieved. Steady state irradiation or femtosecond laser pulses confirm their rapid photofragmentation. Attachment of peptides to the C- and N-termini will provide access
Matthew J Tucker et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(43), 17314-17319 (2013-10-10)
The relaxation of helical structures very close to equilibrium is observed via transient 2D IR spectroscopy. An initial distribution of synthetically distorted helices having an unnatural bridge linking the 10th and 12th residues of an alanine-rich α-helix is released to
Tetrazine phototriggers: probes for peptide dynamics.
Matthew J Tucker et al.
Angewandte Chemie (International ed. in English), 49(21), 3612-3616 (2010-04-15)
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