表单
powder
分子量
504.2
反应适用性
reagent type: cross-linking reagent
储存条件
desiccated
溶解性
water: soluble
运输
ambient
储存温度
−20°C
SMILES字符串
O=C1CC(S(=O)([O-])=O)C(N1OC(C2=CC=C(NC(CI)=O)C=C2)=O)=O.[Na+]
InChI
1S/C13H11IN2O8S.Na/c14-6-10(17)15-8-3-1-7(2-4-8)13(20)24-16-11(18)5-9(12(16)19)25(21,22)23;/h1-4,9H,5-6H2,(H,15,17)(H,21,22,23);/q;+1/p-1
InChI key
HHSGWIABCIVPJT-UHFFFAOYSA-M
一般描述
SIAB is an amine- and sulfhydryl-reactive heterobifunctional crosslinker and Sulfo-SIAB is its water-soluble analog. These crosslinkers contain an amine-reactive N-hydroxysuccimide (NHS) ester and a sulfhyryl-reactive iodoacetyl group, and are often used for preparing enzyme conjugates or immunotoxins. Water-soluble and water-insoluble forms of NHS esters have essentially identical reactivity. Sulfo-SIAB is supplied as a sodium salt and is water-soluble to ~10mM. SIAB must be first dissolved in an organic solvent, such as DMSO or DMF, and then added to the aqueous reaction mixture. SIAB is lipophilic, membrane-permeable and does not possess a charged group.
特点和优势
- Reactive groups: sulfo-NHS ester and iodoacetyl
- Reactive toward: amino and sulfhydryl groups
- Non-cleavable
- Water-soluble (compare to SIAB)
免责声明
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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