804223
3-oxo-C12-aniline
别名:
3-oxo-N-phenyl-Dodecanamide, LasR inhibitor, non-hydrolysable head group
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C18H27NO2
化学文摘社编号:
分子量:
289.41
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.22
SMILES string
CCCCCCCCCC(CC(NC1=CC=CC=C1)=O)=O
InChI
1S/C18H27NO2/c1-2-3-4-5-6-7-11-14-17(20)15-18(21)19-16-12-9-8-10-13-16/h8-10,12-13H,2-7,11,14-15H2,1H3,(H,19,21)
InChI key
GYOZLHQAMICVMN-UHFFFAOYSA-N
form
solid
storage temp.
−20°C
Application
This analog mimics the native 3-oxo-C12 AHL signal utilized by Pseudomonas aeruginosa for quorum sensing, yet contains a non-hydrolysable aniline head group. 3-oxo-C12-aniline is a strong inhibitor of the LasR receptor in P. aeruginosa.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Design, synthesis and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing
McInnis CE, and Blackwell HE
Bioorganic & Medicinal Chemistry, 19, 4812-4819 (2011)
Mutational Analysis of the Quorum-Sensing Receptor LasR Reveals Interactions that Govern Activation and Inhibition by Nonlactone Ligands.
Gerdt JP, et al.
Chemistry & Biology, 21, 1361-1369 (2014)
Grant D Geske et al.
Journal of the American Chemical Society, 129(44), 13613-13625 (2007-10-12)
Bacteria use a language of low molecular weight ligands to assess their population densities in a process called quorum sensing. This chemical signaling process plays a pivotal role both in the pathogenesis of infectious disease and in beneficial symbioses. There
相关内容
We study quorum sensing, how bacteria sense their density. Synthesized compounds modulate pathways, aiding research on infections in various hosts.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持