804223
3-oxo-C12-aniline
别名:
3-oxo-N-phenyl-Dodecanamide, LasR inhibitor, non-hydrolysable head group
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关于此项目
经验公式（希尔记法）:
C18H27NO2
化学文摘社编号:
分子量:
289.41
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.22
Form:
solid
form
solid
storage temp.
−20°C
SMILES string
CCCCCCCCCC(CC(NC1=CC=CC=C1)=O)=O
InChI
1S/C18H27NO2/c1-2-3-4-5-6-7-11-14-17(20)15-18(21)19-16-12-9-8-10-13-16/h8-10,12-13H,2-7,11,14-15H2,1H3,(H,19,21)
InChI key
GYOZLHQAMICVMN-UHFFFAOYSA-N
Application
This analog mimics the native 3-oxo-C12 AHL signal utilized by Pseudomonas aeruginosa for quorum sensing, yet contains a non-hydrolysable aniline head group. 3-oxo-C12-aniline is a strong inhibitor of the LasR receptor in P. aeruginosa.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
相关内容
We study quorum sensing, how bacteria sense their density. Synthesized compounds modulate pathways, aiding research on infections in various hosts.
Mutational Analysis of the Quorum-Sensing Receptor LasR Reveals Interactions that Govern Activation and Inhibition by Nonlactone Ligands.
Gerdt JP, et al.
Chemistry & Biology, 21, 1361-1369 (2014)
Design, synthesis and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing
McInnis CE, and Blackwell HE
Bioorganic & Medicinal Chemistry, 19, 4812-4819 (2011)
Grant D Geske et al.
Journal of the American Chemical Society, 129(44), 13613-13625 (2007-10-12)
Bacteria use a language of low molecular weight ligands to assess their population densities in a process called quorum sensing. This chemical signaling process plays a pivotal role both in the pathogenesis of infectious disease and in beneficial symbioses. There
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 804223-10MG | 04061833232330 |