InChI
1S/C7H9N5/c1-12(2)7-5-6(9-3-8-5)10-4-11-7/h3-4H,1-2H3,(H,8,9,10,11)
InChI key
BVIAOQMSVZHOJM-UHFFFAOYSA-N
SMILES string
CN(C)c1ncnc2[nH]cnc12
assay
98%
法规信息
新产品
此项目有
Masako Okamoto et al.
Bioorganic & medicinal chemistry, 19(1), 486-489 (2010-12-08)
Apoptosis signal-regulating kinase 1 (ASK1, also called MAP3K5) is a mitogen-activated protein kinase kinase kinase (MAP3K) that plays important roles in stress-induced cell death and inflammation, and is expected as a new therapeutic target for cancer, cardiovascular diseases, and neurodegenerative
Oleg Fedorov et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(51), 20523-20528 (2007-12-14)
Protein kinases play a pivotal role in cell signaling, and dysregulation of many kinases has been linked to disease development. A large number of kinase inhibitors are therefore currently under investigation in clinical trials, and so far seven inhibitors have
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