852686
6-巯基嘌呤-9-β-D-核苷
≥95.0% (HPLC)
别名:
6-嘌呤硫醇核苷, 6-巯基嘌呤核苷, 6-硫肌苷
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关于此项目
经验公式（希尔记法）:
C10H12N4O4S
化学文摘社编号:
分子量:
284.29
EC Number:
209-371-5
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
40536
MDL number:
InChI key
NKGPJODWTZCHGF-KQYNXXCUSA-N
InChI
1S/C10H12N4O4S/c15-1-4-6(16)7(17)10(18-4)14-3-13-5-8(14)11-2-12-9(5)19/h2-4,6-7,10,15-17H,1H2,(H,11,12,19)/t4-,6-,7-,10-/m1/s1
SMILES string
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(S)ncnc23
assay
≥95.0% (HPLC)
form
powder
optical activity
[α]/D −74±4°, c = 1% in 0.1 M NaOH
storage temp.
−20°C
Lennard P L Gilissen et al.
Journal of Crohn's & colitis, 6(6), 698-707 (2012-03-09)
Therapeutic drug monitoring of active metabolites of thiopurines, azathioprine and 6-mercaptopurine, is relatively new. The proposed therapeutic threshold level of the active 6-thioguanine nucleotides (6-TGN) is ≥235 pmol/8×10(8) erythrocytes. The aim of this prospective cross-sectional study was to compare 6-TGN
M Ben Sghaier et al.
Environmental toxicology and pharmacology, 31(1), 220-232 (2011-07-27)
The evaluation of the mutagenic and antimutagenic actions of extracts obtained from aerial part of Teucrium ramosissimum was assayed using the Salmonella typhimurium assay system. The effect of the same extracts on genotoxicity and SOS response induced by aflatoxin B(1)
Jaap A Bakker et al.
Nucleosides, nucleotides & nucleic acids, 30(11), 839-849 (2011-11-09)
The role of inosine triphosphatase (ITPase) in adverse drug reactions associated with thiopurine therapy is still under heavy debate. Surprisingly, little is known about the way thiopurines are handled by ITPase. We studied the effect of ITPA polymorphisms on the
Anwar Saad Abd-Elfattah et al.
The Journal of thoracic and cardiovascular surgery, 144(1), 250-255 (2012-02-15)
To determine the role of the p-nitrobenzylthioinosine-sensitive equilibrative nucleoside transporter 1 (es-ENT1) in postmyocardial infarction reperfusion injury-mediated ventricular fibrillation and regional dysfunction. We used erythro-9 (2-hydroxy-3-nonyl)-adenine and p-nitrobenzylthioinosine to inhibit both adenosine deamination and transport in a canine model of
Daniel Pecher et al.
Molecules (Basel, Switzerland), 23(7) (2018-07-19)
Thiopurines (TP) represent an important therapeutic tool for the treatment of inflammatory bowel diseases (IBD) in the current situation of rising incidence and health care costs. The results of multiple clinical studies aimed at finding correlations between levels of TP
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