858781
3,4-二羟基苄胺 氢溴酸盐
98%
别名:
4-(氨甲基)儿茶酚 氢溴酸盐, DHBA 氢溴酸盐
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关于此项目
线性分子式:
(HO)2C6H3CH2NH2 · HBr
化学文摘社编号:
分子量:
220.06
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
240-382-8
Beilstein/REAXYS Number:
4002646
MDL number:
Assay:
98%
Form:
crystals
InChI
1S/C7H9NO2.BrH/c8-4-5-1-2-6(9)7(10)3-5;/h1-3,9-10H,4,8H2;1H
InChI key
BVFZTXFCZAXSHN-UHFFFAOYSA-N
SMILES string
Br.NCc1ccc(O)c(O)c1
assay
98%
form
crystals
mp
184-186 °C (lit.)
functional group
amine
Quality Level
Application
<ul>
<li><strong>3,4-二羟基苯乙胺的氧化聚合：</strong>用3,4-二羟基苯乙胺通过氧化聚合制备聚3,4-二羟基苯乙胺(PDHBA)，说明本品作为多巴胺的偏小类似物(lower homolog)可用于合成与材料科学(Petran et al., 2023)。</li>
<li><strong>尿游离甲氧基肾上腺素类物质的检测：</strong>以3,4-二羟基苯乙胺为内标，提高尿游离甲氧基肾上腺素类物质检测的准确性，用于嗜铬细胞瘤和副神经节瘤诊断。表明临床诊断应用意义(Wang et al., 2020)。</li>
<li><strong>HPLC-ECD方法开发：</strong>以3,4-二羟基苯乙胺为内标，开发HPLC-ECD方法分析血浆中的维生素C。体现其化学性质有利于生化研究的分析方法改进(Clark and Frank, 2016)。</li>
<li><strong>儿茶酚胺类物质的荧光分析：</strong>用3,4-二羟基苯乙胺作为内标测定大鼠脑组织中的儿茶酚胺及相关物质，体现神经化学分析和研究应用价值(Fonseca et al., 2017)。</li>
</ul>
<li><strong>3,4-二羟基苯乙胺的氧化聚合：</strong>用3,4-二羟基苯乙胺通过氧化聚合制备聚3,4-二羟基苯乙胺(PDHBA)，说明本品作为多巴胺的偏小类似物(lower homolog)可用于合成与材料科学(Petran et al., 2023)。</li>
<li><strong>尿游离甲氧基肾上腺素类物质的检测：</strong>以3,4-二羟基苯乙胺为内标，提高尿游离甲氧基肾上腺素类物质检测的准确性，用于嗜铬细胞瘤和副神经节瘤诊断。表明临床诊断应用意义(Wang et al., 2020)。</li>
<li><strong>HPLC-ECD方法开发：</strong>以3,4-二羟基苯乙胺为内标，开发HPLC-ECD方法分析血浆中的维生素C。体现其化学性质有利于生化研究的分析方法改进(Clark and Frank, 2016)。</li>
<li><strong>儿茶酚胺类物质的荧光分析：</strong>用3,4-二羟基苯乙胺作为内标测定大鼠脑组织中的儿茶酚胺及相关物质，体现神经化学分析和研究应用价值(Fonseca et al., 2017)。</li>
</ul>
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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An assay of norepinephrine (NE), epinephrine (E), dopamine (DA), normetanephrine (NE) and metanephrine (MN) based on high-performance liquid chromatography (HPLC) in combination with atmospheric pressure chemical ionization mass spectrometry (APcI-MS) is described. The catecholamines and metanephrines were extracted from urine
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Buthionine sulfoximine (BSO), a specific inhibitor of glutathione synthesis, showed variable growth-inhibitory activity in different tumor cell lines with a high degree of inhibitory activity against melanoma-derived cell lines. A correlation between BSO growth-inhibitory effects and cellular glutathione peroxidase activity
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