858781
3,4-二羟基苄胺 氢溴酸盐
98%
别名:
4-(氨甲基)儿茶酚 氢溴酸盐, DHBA 氢溴酸盐
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关于此项目
线性分子式:
(HO)2C6H3CH2NH2 · HBr
化学文摘社编号:
分子量:
220.06
Beilstein:
4002646
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
质量水平
方案
98%
表单
crystals
mp
184-186 °C (lit.)
官能团
amine
SMILES字符串
Br.NCc1ccc(O)c(O)c1
InChI
1S/C7H9NO2.BrH/c8-4-5-1-2-6(9)7(10)3-5;/h1-3,9-10H,4,8H2;1H
InChI key
BVFZTXFCZAXSHN-UHFFFAOYSA-N
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应用
<ul>
<li><strong>3,4-二羟基苯乙胺的氧化聚合：</strong>用3,4-二羟基苯乙胺通过氧化聚合制备聚3,4-二羟基苯乙胺(PDHBA)，说明本品作为多巴胺的偏小类似物(lower homolog)可用于合成与材料科学(Petran et al., 2023)。</li>
<li><strong>尿游离甲氧基肾上腺素类物质的检测：</strong>以3,4-二羟基苯乙胺为内标，提高尿游离甲氧基肾上腺素类物质检测的准确性，用于嗜铬细胞瘤和副神经节瘤诊断。表明临床诊断应用意义(Wang et al., 2020)。</li>
<li><strong>HPLC-ECD方法开发：</strong>以3,4-二羟基苯乙胺为内标，开发HPLC-ECD方法分析血浆中的维生素C。体现其化学性质有利于生化研究的分析方法改进(Clark and Frank, 2016)。</li>
<li><strong>儿茶酚胺类物质的荧光分析：</strong>用3,4-二羟基苯乙胺作为内标测定大鼠脑组织中的儿茶酚胺及相关物质，体现神经化学分析和研究应用价值(Fonseca et al., 2017)。</li>
</ul>
<li><strong>3,4-二羟基苯乙胺的氧化聚合：</strong>用3,4-二羟基苯乙胺通过氧化聚合制备聚3,4-二羟基苯乙胺(PDHBA)，说明本品作为多巴胺的偏小类似物(lower homolog)可用于合成与材料科学(Petran et al., 2023)。</li>
<li><strong>尿游离甲氧基肾上腺素类物质的检测：</strong>以3,4-二羟基苯乙胺为内标，提高尿游离甲氧基肾上腺素类物质检测的准确性，用于嗜铬细胞瘤和副神经节瘤诊断。表明临床诊断应用意义(Wang et al., 2020)。</li>
<li><strong>HPLC-ECD方法开发：</strong>以3,4-二羟基苯乙胺为内标，开发HPLC-ECD方法分析血浆中的维生素C。体现其化学性质有利于生化研究的分析方法改进(Clark and Frank, 2016)。</li>
<li><strong>儿茶酚胺类物质的荧光分析：</strong>用3,4-二羟基苯乙胺作为内标测定大鼠脑组织中的儿茶酚胺及相关物质，体现神经化学分析和研究应用价值(Fonseca et al., 2017)。</li>
</ul>
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
F Boomsma et al.
Journal of chromatography, 621(1), 82-88 (1993-11-17)
We report a rapid breakdown of dopamine and especially of 3,4-dihydroxybenzylamine, the frequently-used internal standard in catecholamine determinations, in plasma of many but not all animal species. Species investigated were cow, sheep, goat, pig, horse, rabbit, dog, guinea pig, mouse
Sophie Bourcier et al.
European journal of mass spectrometry (Chichester, England), 9(4), 351-360 (2003-08-27)
Our research into neurotransmitters in a biological fluid presented an opportunity to investigate the fragmentations under low collision energy characterising benzyl-amines protonated under electrospray ionisation (ESI) conditions in a triple quadrupole mass spectrometer. In this work we present the breakdown
M Sugumaran
Pigment cell research, 8(5), 250-254 (1995-10-01)
Dopamine and related compounds are known to be toxic to melanoma cells. Some of their toxicity may be related, in part, to the oxidation products generated from them upon their interaction with melanogenic enzymes. In this paper, we present our
G Santagostino et al.
Farmaco (Societa chimica italiana : 1989), 46(10), 1217-1223 (1991-10-01)
A simple routine method is described for simultaneous assay of total urinary norepinephrine, epinephrine, dopamine, normetanephrine and metanephrine. An internal standard of 3,4 dihydroxybenzylamine is added to the diluted urine and acidic hydrolysis of the conjugates is followed by reverse-phase
C Gerin et al.
Journal of neuroscience methods, 66(2), 81-92 (1996-06-01)
The aim of the microdialysis technique is to reflect as closely as possible the status and fluctuations of substances contained in the extracellular space. Most often, microdialysis is performed with repetitively implanted probes. We have recently devised an experimental set-up
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