860360
阿霉素 盐酸盐
98%
别名:
DOX, 多柔比星® 盐酸盐, 羟基柔红霉素 盐酸盐
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关于此项目
经验公式（希尔记法）:
C27H29NO11 · HCl
化学文摘社编号:
分子量:
579.98
Beilstein:
4229251
EC 号:
MDL编号:
UNSPSC代码:
12352103
方案
98%
mp
216 °C (dec.) (lit.)
SMILES字符串
Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
InChI
1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
InChI key
MWWSFMDVAYGXBV-RUELKSSGSA-N
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应用
Inhibitor of RNA synthesis. Compound employed in antitumor activity studies.
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L H Li et al.
Biochemistry and molecular biology international, 31(5), 879-887 (1993-12-01)
The transcriptional effect of adriamycin using E. coli RNA polymerase on several single- and double-stranded DNAs of known base content and sequence is studied in vitro. The results show that adriamycin inhibits strongly and with little difference toward both poly[d(A-T)]
A Berczi et al.
Archives of biochemistry and biophysics, 300(1), 356-363 (1993-01-01)
Adriamycin (ADR) was coupled to human transferrin (TRF) by using a glutaraldehyde crosslinking method. The TRF-ADR conjugates were separated by column chromatography and the molar ratio of ADR to TRF (i.e., conjugation number) for the studied conjugates was found to
Nashwa M Abu-Elsaad et al.
Journal of medicinal food, 18(9), 950-959 (2015-01-16)
Probiotics and antioxidants have a definite improving effect in cardiovascular diseases. This study aims at mitigating doxorubicin toxicity on cardiac function through consuming a functional food. Five groups of adult male Sprague-Dawley rats were used along 22 weeks. Group I
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