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Merck
CN

901186

吡啶基二硫化甲基丙烯酸乙酯

≥98.0%, contains 150 ppm MEHQ as inhibitor

别名:

2-甲基二吡啶基二甲基丙烯酸酯, PDSEMA

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关于此项目

经验公式(希尔记法):
C11H13NO2S2
化学文摘社编号:
分子量:
255.36
UNSPSC Code:
12352005
NACRES:
NA.23
MDL number:
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assay

≥98.0%

form

liquid

contains

150 ppm MEHQ as inhibitor

color

colorless to pale yellow

shipped in

wet ice

storage temp.

−20°C

General description

吡啶基二硫化甲基丙烯酸乙酯是一种基于甲基丙烯酸酯的单体,用于合成聚(吡啶基二硫化甲基丙烯酸乙酯)[p(PDSMA)]和其他共聚物。p(PDSMA)包含一个受保护的侧基硫醇,可用于通过硫醇-二硫键交换反应进行聚合后官能化。另外,反应进程通常可以通过吸收光谱法进行监测,因为释放的 2-吡啶硫酮的光谱特征(λ max= 375 nm)与聚合物中的吡啶基二硫化官能度(λ max= 280 nm)明显不同。由于它们的多功能性,这些材料已用于多种生物医学应用中,例如聚合物-生物分子缀合物的合成和药物递送应用。

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

230.0 °F

flash_point_c

110 °C


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Xiaotian Ji et al.
Colloids and surfaces. B, Biointerfaces, 148, 41-48 (2016-11-05)
In this paper a novel method for the fabrication of hybrid nanogels based on thiol-disulfide exchange reaction is reported. Poly(oligo(ethylene glycol) monomethyl ether methacrylate-co-di(ethylene glycol) methyl ether methacrylate-co-2-(2-pyridyldisulfide) ethyl methacrylate) (POEGMA-co-PDEGMA-co-PDSMA) was synthesized by reversible addition-fragmentation chain transfer polymerization. Pyridyl
Nicholas M Matsumoto et al.
Polymer chemistry, 4(8), 2464-2469 (2014-04-25)
The covalent conjugation of bovine serum albumin (BSA) to disulfide cross-linked polymeric nanogels is reported. Polymeric nanogel precursors were synthesized via a reversible addition-fragmentation chain transfer (RAFT) random copolymerization of poly(ethylene glycol) methyl ether methacrylate (PEGMA) and pyridyl disulfide methacrylate
Reactive Copolymers Based on N-Vinyl Lactams with Pyridyl Disulfide Side Groups via RAFT Polymerization and Postmodification via Thiol-Disulfide Exchange Reaction.
Peng H, et al.
Macromolecules, 49(19), 7141-7154 (2016)
Simultaneous and Reversible Functionalization of Copolymers for Biological Applications.
Ghosh S, et al.
Macromolecules, 39(17), 5595-5597 (2006)
Judy Ventura et al.
Biomacromolecules, 16(10), 3161-3171 (2015-09-04)
Conjugation of biologically active proteins to polymeric materials is of great interest in the treatment of cancer and other diseases of protein deficiency. The conjugation of such biomacromolecules is challenging both due to their hydrophilicity and propensity to denature under

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