906107
(9-Aminononyl)triphenylphosphonium bromide
90%
别名:
Aminononane TPP mitochondrial tag, Mitochondria-targeting probe building block, Phosphonium lipocation tag
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关于此项目
经验公式（希尔记法）:
C27H35BrNP
分子量:
484.45
UNSPSC Code:
12352200
Assay:
90%
Form:
powder
assay
90%
form
powder
storage temp.
2-8°C
SMILES string
NCCCCCCCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3.[Br-]
Application
Mitochondria perform several functions in the cell, and dysfunction has been implicated in various organ systems and disease states, including neurodegenerative disorders, cardiovascular diseases, and cancers. The targeting of small molecules to the mitochondria can help to probe and better understand this relationship or to increase therapeutic efficacy by concentrating a drug at its site of action and reducing off-target effects. This bromohexane triphenylphosphine (TPP) tag is conjugated to small molecules to localize them to the mitochondria in cells where the TPP cations facilitate both cellular uptake and accumulation in the mitochondria.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Yon Ju-Nam et al.
Organic & biomolecular chemistry, 4(23), 4345-4351 (2006-11-15)
We report the synthesis and structural characterisation of a new family of stable phosphonioalkylthiosulfate zwitterions, R3P+ (CH2)nS2O3- (R = Ph or Bu, n = 3,4,6, 8 or 10) which behave as cationic masked thiolate ligands with applications in the functionalisation
Changwook Lee et al.
Journal of the American Chemical Society, 137(13), 4358-4367 (2015-03-19)
The mitochondrial pool of Hsp90 and its mitochondrial paralogue, TRAP1, suppresses cell death and reprograms energy metabolism in cancer cells; therefore, Hsp90 and TRAP1 have been suggested as target proteins for anticancer drug development. Here, we report that the actual
Marcel Culcasi et al.
Journal of medicinal chemistry, 56(6), 2487-2499 (2013-02-27)
A series of mitochondria targeted α-aminophosphonates combining a diethoxyphosphoryl group and an alkyl chain-connected triphenylphosphonium bromide tail were designed and synthesized, and their pH-sensitive (31)P NMR properties and biological activities in vitro and in vivo were evaluated. The results showed