906719
Pyrylium tetrafluoroborate
≥95%
别名:
Pyry-BF4
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关于此项目
经验公式（希尔记法）:
C5H5BF4O
化学文摘社编号:
分子量:
167.90
MDL number:
UNSPSC Code:
12352107
NACRES:
NA.22
InChI key
SJNICXIZTGPXAU-UHFFFAOYSA-N
InChI
1S/C5H5O.BF4/c1-2-4-6-5-3-1;2-1(3,4)5/h1-5H;/q+1;-1
SMILES string
[B-](F)(F)(F)F.[o+]1ccccc1
assay
≥95%
form
powder
storage temp.
2-8°C
Application
Pyrylium tetrafluoroborate is used for the functionalization of heterocyclic amines, activating them for nucleophilic substitution. As demonstrated by the Cornella lab, the intermediate pyridinium salts can react with a vast array of nucelophiles to form new C-N, C-O, and C-S bonds, making pyrylium tetrafluoroborate a valuable reagent for late-stage functionalization.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Daniel Moser et al.
Angewandte Chemie (International ed. in English), 57(34), 11035-11039 (2018-07-04)
The functionalization of aminoheterocycles by using a pyrylium tetrafluoroborate reagent (Pyry-BF4 ) is presented. This reagent efficiently condenses with a great variety of heterocyclic amines and primes the C-N bond for nucleophilic aromatic substitution. More than 60 examples for the
相关内容
The main focus of the Cornella research group is the development of rapid, practical and efficient methodologies for organic synthesis. In addition to efficiency and practicality, the group is highly interested in discovering new reactivity with the aim of unveiling novel transformations. More specifically, on the fundamental understanding and application of catalytic processes and the development of simple reagents. These two approaches have enormous potential and impact across the chemical sciences.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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