907197
1,4-Dinitro-1-imidazole
别名:
1,4-DNIm, 1,4-Dinitroimidazole, Bifunctional bioconjugation reagent
InChI
1S/C3H2N4O4/c8-6(9)3-1-5(2-4-3)7(10)11/h1-2H
InChI key
HZPSREFSUPXCMN-UHFFFAOYSA-N
assay
≥95%
form
solid
storage temp.
−20°C
Application
1,4-Dinitro-1-imidazole (1,4-DNIm) and other dinitroimidazoles were demonstrated to be bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization. In acidic to neutral aqueous conditions, 1,4-DNIms chemoselectively react with cysteines; in organic solvents in the presence of base, 1,4-DNIms chemoselectively react with lysines to form stable conjugates
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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