5-Norbornene-2-carboxylate NHS ester

Name: 5-Norbornene-2-carboxylate NHS ester
Brand: ALDRICH

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About This Item

经验公式（希尔记法）:

C₁₂H₁₃NO₄

CAS Number:

457630-22-7

分子量:

235.24

MDL编号:

MFCD26792806

方案

>90% (HPLC)

质量水平

100

溶解性

chloroform: 15 mg (/0.5ml)

储存温度

2-8°C

SMILES字符串

O=C1CCC(N1OC(C2C3C=CC(C3)C2)=O)=O

一般描述

5-Norbornene-2-carboxylate NHS Ester is a versatile and functional compound designed for a wide range of applications in bioconjugation and polymer chemistry. This compound features an N-Hydroxysuccinimide (NHS) ester, which allows for efficient reactions with amine-containing compounds, such as lysine residues on proteins and peptides. The norbornene structure facilitates bioorthogonal reactions, particularly the inverse electron demand Diels-Alder cycloaddition with 1,2,4,5-tetrazines, making it invaluable for biological imaging and advanced polymer synthesis.

应用

5-Norbornene-2-carboxylate NHS Ester is used in a wide range of applications including:

Protein Labeling: Efficiently labels proteins and peptides through reactions with amines.
Conjugate Preparation: Prepares conjugates for immunoassays and other analytical techniques.
Fluorescent Labeling: Facilitates the labeling of enzymes for detection and analysis.
Enzyme Immobilization: Works with EDC to immobilize enzymes for biosensor applications.

Its unique combination of NHS ester and norbornene functionalities makes it a powerful tool for researchers aiming to advance bioconjugation techniques, develop novel materials, and enhance biological imaging methods.