94324
Deoxo-Fluor 溶液
~50% in toluene (NMR)
别名:
双(2-甲氧基乙基)氨基三氟化硫 溶液
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关于此项目
经验公式（希尔记法）:
C6H14F3NO2S
化学文摘社编号:
分子量:
221.24
UNSPSC Code:
12352101
PubChem Substance ID:
MDL number:
form
liquid
concentration
~50% in toluene (NMR)
color
clear yellow
storage temp.
2-8°C
SMILES string
COCCN(CCOC)S(F)(F)F
InChI
1S/C6H14F3NO2S/c1-11-5-3-10(4-6-12-2)13(7,8)9/h3-6H2,1-2H3
InChI key
APOYTRAZFJURPB-UHFFFAOYSA-N
Application
Reactant for:
- Fluorination reactions
- Preparation of fluorinated catechols via Umpolung based nucleophilic deoxyfluorination
- Preparation of imidazole derivatives as CXCR3 antagonists
- Ring expansion reactions
- Synthesis of acyl azides from carboxylic acids
- Aldehydes or ketones from carboxylic acids and Grignard reagents via in situ generation of Weinreb amides
Other Notes
具有高热稳定性的氟化剂
Legal Information
signalword
Danger
target_organs
Central nervous system, Respiratory system
存储类别
4.3 - Hazardous materials which set free flammable gases upon contact with water
wgk
WGK 3
flash_point_f
<50.0 °F - closed cup
flash_point_c
< 10 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Skin Corr. 1A - STOT RE 2 - STOT SE 3 - Water-react. 2
法规信息
新产品
此项目有
Rajendra P Singh et al.
The Journal of organic chemistry, 68(15), 6063-6065 (2003-07-19)
New alpha,alpha-difluoroamides (4a-d, 6a-d) and alpha-ketoamides (5a-d, 7a-d) result from one-pot reactions of alpha-ketoacids, RCOCO(2)H (R = C(6)H(5), CH(3), CH(3)CH(2), thienyl) (1a-d) with bis(2-methoxyethyl)aminosulfur trifluoride [(CH(3)OCH(2)CH(2))(2)NSF(3)] (2) (Deoxofluor) or diethylaminosulfur trifluoride [(CH(3)CH(2))(2)NSF(3))] (3) (DAST). Product yields depend on reaction times
R.P. Singh, J.M. Shreeve
Journal of Fluorine Chemistry, 116, 23-23 (2002)
Lal et al.
The Journal of organic chemistry, 65(16), 4830-4832 (2000-08-24)
A variety of thiocarbonyl derivatives (thioketone, thioester, thioamide, dithioester, and dithiocarbamate) were converted to the corresponding gem-difluorides in excellent yields on reaction with the fluorinating agent, bis(2-methoxyethyl)aminosulfur trifluoride, in the presence of SbCl(3).