943401
1-(6-Bromo-1-methylindazol-3-yl)hexahydropyrimidine-2,4-dione
≥95%
别名:
(6-Bromo-1-methylindazol-3-yl)-1,3-diazinan-2,4-dione, 1-(6-Bromo-1-methyl-1H-indazol-3-yl)dihydro-2,4(1H,3H)-pyrimidinedione, 1-(6-Bromo-1-methylindazol-3-yl)-1,3-diazinane-2,4-dione, 2,4(1H,3H)-Pyrimidinedione, 1-(6-bromo-1-methyl-1H-indazol-3-yl)dihydro-
描述
Reaction suitability: A functionalized CRBN ligand for development of small molecule degraders
质量水平
方案
≥95%
表单
amorphous solid
颜色
pale yellow to beige
官能团
(Bromide functionality for incorporating linker)
储存温度
2-8°C
SMILES字符串
O=C1NC(CCN1C2=NN(C)C3=C2C=CC(Br)=C3)=O
InChI
InChI=1S/C12H11BrN4O2/c1-16-9-6-7(13)2-3-8(9)11(15-16)17-5-4-10(18)14-12(17)19/h2-3,6H,4-5H2,1H3,(H,14,18,19)
InChI key
FVEJZRXMQPIZQZ-UHFFFAOYSA-N
一般描述
This compound is a dihydropyrimidine-dione derivative, featuring an indazole ring substituted with a bromine and a methyl group, linked to a dihydropyrimidinedione moiety.
应用
A functionalized CRBN ligand for synthesis of small molecule degraders.
特点和优势
Bromide functionality is useful for incorporating linker for choice for degrader diversity.
法规信息
新产品
此项目有
Small-Molecule PROTACS: New Approaches to Protein Degradation
Toure M,et.al
Angewandte Chemie (International ed. in English), 55, 1966-1973 (2016)
Targeted Protein Degradation by Small Molecules
Bondeson DP,et.al
Annual Review of Pharmacology and Toxicology, 57, 107-123 (2017)
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Cromm PM,et.al
Cell Chemical Biology (2017)
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