943401
1-(6-Bromo-1-methylindazol-3-yl)hexahydropyrimidine-2,4-dione
≥95%
别名:
(6-Bromo-1-methylindazol-3-yl)-1,3-diazinan-2,4-dione, 1-(6-Bromo-1-methyl-1H-indazol-3-yl)dihydro-2,4(1H,3H)-pyrimidinedione, 1-(6-Bromo-1-methylindazol-3-yl)-1,3-diazinane-2,4-dione, 2,4(1H,3H)-Pyrimidinedione, 1-(6-bromo-1-methyl-1H-indazol-3-yl)dihydro-
InChI key
FVEJZRXMQPIZQZ-UHFFFAOYSA-N
InChI
InChI=1S/C12H11BrN4O2/c1-16-9-6-7(13)2-3-8(9)11(15-16)17-5-4-10(18)14-12(17)19/h2-3,6H,4-5H2,1H3,(H,14,18,19)
SMILES string
O=C1NC(CCN1C2=NN(C)C3=C2C=CC(Br)=C3)=O
description
Reaction suitability: A functionalized CRBN ligand for development of small molecule degraders
assay
≥95%
form
amorphous solid
color
pale yellow to beige
functional group
(Bromide functionality for incorporating linker)
storage temp.
2-8°C
Quality Level
General description
This compound is a dihydropyrimidine-dione derivative, featuring an indazole ring substituted with a bromine and a methyl group, linked to a dihydropyrimidinedione moiety.
Application
A functionalized CRBN ligand for synthesis of small molecule degraders.
Features and Benefits
Bromide functionality is useful for incorporating linker for choice for degrader diversity.
法规信息
新产品
此项目有
Targeted Protein Degradation by Small Molecules
Bondeson DP,et.al
Annual Review of Pharmacology and Toxicology, 57, 107-123 (2017)
Small-Molecule PROTACS: New Approaches to Protein Degradation
Toure M,et.al
Angewandte Chemie (International ed. in English), 55, 1966-1973 (2016)
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Cromm PM,et.al
Cell Chemical Biology (2017)
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