质量水平
方案
≥95%
表单
amorphous solid
颜色
off-white to gray-brown
官能团
(hydroxymethyl substitution at the 4-position and a diethylamino group at the 7-position)
储存温度
2-8°C
SMILES字符串
O=C1OC=2C=C(C=CC2C(=C1)CO)N(CC)CC
InChI
InChI=1S/C14H17NO3/c1-3-15(4-2)11-5-6-12-10(9-16)7-14(17)18-13(12)8-11/h5-8,16H,3-4,9H2,1-2H3
InChI key
NMZSXNOCNJMJQT-UHFFFAOYSA-N
一般描述
7-(Diethylamino)-4-(hydroxymethyl)coumarin, commonly abbreviated DEACM, is a coumarin-based fluorescent compound widely used as a photoremovable protecting group (PPG) and fluorescent probe. It belongs to the class of coumarin derivatives, featuring a hydroxymethyl substitution at the 4-position and a diethylamino group at the 7-position, giving it strong photophysical properties.
应用
A coumarin derivative useful for generation of photocontrolled PROTACs(photoPROTACs) that can cause on demand degradation using 365nm light.
特点和优势
DEACM absorbs light in the near-UV to blue region (~365 nm) and exhibits bright fluorescence, making it especially valuable for photo-controlled release applications (“caging” techniques), biological imaging, and fluorescent sensing. Because of its excellent quantum yield and chemical stability, DEACM is widely adopted in fields such as chemical biology, pharmaceutical R&D, photochemistry, and analytical sciences.
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