943576
3-(4-(Piperazin-1-yl)phenyl)piperidine-2,6-dione dihydrochloride
≥95%
别名:
2,6-Piperidinedione, 3-[4-(1-piperazinyl)phenyl]-, hydrochloride (1:2), Phenyl-glutarimide 4′-piperazine
SMILES string
O=C1NC(C(CC1)C2=CC=C(N3CCNCC3)C=C2)=O.[2HCl]
InChI key
DUZCAOXBUQOLHN-UHFFFAOYSA-N
InChI
1S/C15H19N3O2.2ClH/c19-14-6-5-13(15(20)17-14)11-1-3-12(4-2-11)18-9-7-16-8-10-18;;/h1-4,13,16H,5-10H2,(H,17,19,20);2*1H
description
Amine Reactivity: The free piperazine nitrogen(s) can undergo alkylation, acylation, or conjugation using standard coupling strategies (e.g., NHS esters, amide bonds). / Linker Compatibility: Ideal for joining target-binding ligands via PROTAC synthetic workflows.
assay
≥95%
form
amorphous solid
reaction suitability
reactivity: amine reactive
color
off-white to gray-brown
functional group
amine (The free piperazine nitrogen(s) can undergo alkylation, acylation, or conjugation using standard coupling strategies (e.g., NHS esters, amide bonds).)
storage temp.
−20°C
Quality Level
General description
Application
- PROTAC Assembly: Functions as the E3 ligase ligand, especially in PG-PROTAC systems for targeted protein degradation.
- Chemical Biology Research: Used in studies of targeted degradation mechanisms and new degrader development.
- Medicinal Chemistry: Acts as a scaffold for scaffold-based drug design and bifunctional molecule synthesis.
Features and Benefits
- Reliable cereblon engagement: Binds the CRBN E3 ligase, facilitating PROTAC assembly.
- Enhanced hydrolytic stability: Outperforms IMiD-based ligands (e.g., thalidomide derivatives) in chemical durability.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Irrit. 2 - Skin Sens. 1B
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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