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线性分子式:
C6H5CH2OOCNH(CH2)4CH(NH2)COOH
化学文摘社编号:
分子量:
280.32
NACRES:
NA.22
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
214-585-7
MDL number:
Beilstein/REAXYS Number:
2222482
产品名称
H-Lys(Z)-OH, ≥99.0% (NT)
InChI
1S/C14H20N2O4/c15-12(13(17)18)8-4-5-9-16-14(19)20-10-11-6-2-1-3-7-11/h1-3,6-7,12H,4-5,8-10,15H2,(H,16,19)(H,17,18)/t12-/m0/s1
InChI key
CKGCFBNYQJDIGS-LBPRGKRZSA-N
SMILES string
N[C@@H](CCCCNC(=O)OCc1ccccc1)C(O)=O
assay
≥99.0% (NT)
form
powder
optical activity
[α]20/D +15.5±1°, c = 1% in 1 M HCl
reaction suitability
reaction type: solution phase peptide synthesis
mp
259 °C (dec.) (lit.)
application(s)
peptide synthesis
Quality Level
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Application
H-Lys(Z)-OH serves as a reactant for the synthesis of various peptides such as boc-Glu(OBzl)-Lys(Z)-OH and tert-butyl-6-(((benzyloxy)carbonyl)amino)-2-bromohexanoate. Additionally, it is used in the Fuchs-Farthing method to synthesize lysine NCA, which is a block copolymer.
General description
H-Lys(Z)-OH also known as N6-carbobenzyloxy-L-lysine, commonly used as a reagent in the synthesis of peptides.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Poly (ethylene glycol)-b-poly (lysine) copolymer bearing nitroaromatics for hypoxia-sensitive drug delivery
T Thambi
Acta Biomaterialia, 29, 261-270 (2016)
Preparation of protected peptide intermediates for a synthesis of the ovine pituitary growth hormone sequence 96-135
SS Wang
The Journal of Organic Chemistry, 40, 1227-1234 (1975)
Synthesis and characterization of pH-sensitive, biotinylated MRI contrast agents and their conjugates with avidin
SM Vibhute
Organic & Biomolecular Chemistry, 11, 1294-1305 (2013)
R L Hanson et al.
Applied microbiology and biotechnology, 37(5), 599-603 (1992-08-01)
Biotransformations were developed to oxidize N epsilon-carbobenzoxy(CBZ)-L-lysine and to reduce the product keto acid to L-CBZ-oxylysine. Lysyl oxidase (L-lysine: O2 oxidoreductase, EC 1.4.3.14) from Trichoderma viride was relatively specific for L-lysine and had very low activity with N epsilon-substituted derivatives.
J Zheng et al.
Biotechnology progress, 16(2), 254-257 (2000-04-08)
Poly(epsilon-CBZ-L-lysine) can be mixed with biodegradable polymers such as poly(D,L-lactic-co-glycolic acid) or poly(L-lactic acid) and formed into films, foams, or microspheres. Surface amino groups may then be deprotected with acid or lithium/liquid ammonia. The amino groups serve as a method
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