A8309
乙酰肼
90%
别名:
Acetic acid hydrazide, Acetylhydrazine
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关于此项目
线性分子式:
CH3CONHNH2
化学文摘社编号:
分子量:
74.08
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
213-948-7
Beilstein/REAXYS Number:
506165
MDL number:
Assay:
90%
Form:
flakes
InChI
1S/C2H6N2O/c1-2(5)4-3/h3H2,1H3,(H,4,5)
InChI key
OFLXLNCGODUUOT-UHFFFAOYSA-N
SMILES string
CC(=O)NN
assay
90%
form
flakes
impurities
<10% acetic acid
bp
129 °C/18 mmHg (lit.)
Quality Level
General description
乙酰肼是一种有机合成砌块，可通过催化氢化反应生成 N′-甲基乙酰肼(MAH)。
Application
乙酰乙肼可用于合成(E)-N′-（2-羟基亚苄基）乙酰肼，这是一种 ONO 钳形配体。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Carc. 2 - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Shahrzad Tafazoli et al.
Toxicology and applied pharmacology, 229(1), 94-101 (2008-02-26)
Isoniazid is an anti-tuberculosis drug that can cause hepatotoxicity in 20% of patients that is usually associated with an inflammatory response. Hepatocytes when exposed to non-toxic levels of H2O2, to simulate H2O2 formation by inflammatory cells, became twice as sensitive
N E Preece et al.
Journal of chromatography, 573(2), 227-234 (1992-01-17)
Plasma and liver levels of hydrazine were determined at 10, 30, 90 and 270 min in rats given 0.09, 0.27, 0.84 and 2.53 mmol of hydrazine per kg body weight orally by capillary gas chromatography-mass spectrometry of its pentafluorobenzaldehyde adduct
Victoria E Richards et al.
Toxicological sciences : an official journal of the Society of Toxicology, 82(1), 318-332 (2004-07-30)
Hydrazine (HD) and acetylhydrazine (AcHD) are metabolites of the antituberculosis drug isoniazid (INH) that have been implicated in INH-induced liver damage. The hepatotoxicity of AcHD and HD were compared in adult male C57Bl/6J mice by evaluating hepatic histopathology, plasma biochemistry
D J Fort et al.
Teratogenesis, carcinogenesis, and mutagenesis, 10(6), 463-476 (1990-01-01)
The developmental toxicity of isoniazid (INH) and the metabolites acetylhydrazide (AH) and isonicotinic acid (INA) were examined with the frog embryo teratogenesis assay-Xenopus (FETAX). Late Xenopus laevis blastulae were exposed to INH, AH, and INA for 96 h in two
B K Sinha
Biochimica et biophysica acta, 924(2), 261-269 (1987-05-19)
Spin-trapping techniques and electron spin resonance spectroscopy have been used to study bioactivations of hydrazine and its derivatives by isolated perfused rat livers. Using phenylbutylnitrone (PBN) as the stable spin trap, it was found that the liver perfusion of hydrazine
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