C8601
Z-Pro-OH
99%
别名:
Z-L-脯氨酸
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关于此项目
经验公式（希尔记法）:
C13H15NO4
化学文摘社编号:
分子量:
249.26
NACRES:
NA.22
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
214-557-4
MDL number:
Beilstein/REAXYS Number:
88579
产品名称
Z-Pro-OH, 99%
InChI
1S/C13H15NO4/c15-12(16)11-7-4-8-14(11)13(17)18-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H,15,16)/t11-/m0/s1
InChI key
JXGVXCZADZNAMJ-NSHDSACASA-N
SMILES string
OC(=O)[C@@H]1CCCN1C(=O)OCc2ccccc2
assay
99%
form
powder or crystals
optical activity
[α]20/D −42°, c = 2 in ethanol
reaction suitability
reaction type: solution phase peptide synthesis
technique(s)
NMR: suitable
color
white
mp
76-78 °C (lit.)
application(s)
peptide synthesis
Quality Level
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Application
Z-Pro-OH can be used:
- As a starting material to prepare aib-pro endothiopeptides of pharmacological importance.
- To prepare biologically significant fluorophore-labeled peptide tetramers or dimers.
- As a reactant to synthesize benzoxazole derived human neutrophil elastase (HNE) inhibitors.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
A new dendrimer scaffold for preparing dimers or tetramers of biologically active molecules
Raju N, et al.
Tetrahedron Letters, 46(9), 1463-1465 (2005)
Design and synthesis of peptide-based carboxylic acid-containing transition-state inhibitors of human neutrophil elastase
Sato F, et al.
Bioorganic & medicinal chemistry letters, 12(4), 551-555 (2002)
The `azirine/oxazolone approach?to the synthesis of Aib-Pro endothiopeptides
Budzowski A, et al.
Helvetica Chimica Acta, 91(8), 1471-1488 (2008)
Cytotoxicity of carbobenzoxy-protected amino acids.
M Dolenga et al.
In vitro cellular & developmental biology : journal of the Tissue Culture Association, 28A(5), 300-302 (1992-05-01)
Arkadiusz Surazynski et al.
European journal of pharmacology, 649(1-3), 115-119 (2010-09-28)
Transforming growth factor beta 1 (TGF β1) is a protein that in most cells control proliferation and differentiation. One of the best characterized functions of TGF β1 is stimulation of collagen biosynthesis that may lead to tissue fibrosis. Several reports
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