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Merck
CN

D5431

Sigma-Aldrich

2-(N,N-二乙基氨基)-二氮烯-2-氧 二乙铵盐

≥98%

别名:

DEA NONOate, DEA/无二乙基铵盐

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关于此项目

线性分子式:
(CH3CH2)2N–N(N=O)O- (CH3CH2)2NH2+
化学文摘社编号:
372965-00-9
分子量:
206.29
MDL编号:
MFCD00216152
UNSPSC代码:
12352116
PubChem化学物质编号:
329798805
NACRES:
NA.22

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描述

t1/2 16 min phosphate buffer, 22 °C NO release

方案

≥98%

表单

solid

运输

dry ice

储存温度

−70°C

SMILES字符串

CCNCC.CCN(CC)N(O)N=O

InChI

1S/C4H11N3O2.C4H11N/c1-3-6(4-2)7(9)5-8;1-3-5-4-2/h9H,3-4H2,1-2H3;5H,3-4H2,1-2H3

InChI key

LBJLVZKEUWCGIA-UHFFFAOYSA-N

应用

DEA/NO二乙基铵盐可以用作：        
  • 一氧化氮 (NO) 供体。
  • 用于Wilkinson′s催化剂还原亚硝基化的试剂

用作：
  • 威尔金森还原亚硝基化试剂催化剂
  • 一氧化氮 (NO) 供体

生化/生理作用

NO 供体

象形图

CorrosionExclamation mark
GHS05,GHS07

警示用语：

Danger

危险分类

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

监管及禁止进口产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLCK9803
SLCH3638
SLCD6671
SLCB8130
SLBS2808V

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Xin Zhang et al.
The Journal of biological chemistry, 277(50), 48472-48478 (2002-10-09)
4,5-Diaminofluorescein (DAF-2) is widely used for detection and imaging of NO based on its sensitivity, noncytotoxicity, and specificity. In the presence of oxygen, NO and NO-related reactive nitrogen species nitrosate 4,5-diaminofluorescein to yield the highly fluorescent DAF-2 triazole (DAF-2T). However
Xi Ye et al.
The Journal of physiology, 596(16), 3553-3566 (2018-06-05)
Prolonged exposure to vascular endothelial growth factor A (VEGF-A) inhibits agonist-mediated endothelial cell Ca2+ release and subsequent activation of intermediate conductance Ca2+ -activated K+ (IKCa ) channels, which underpins vasodilatation as a result of endothelium-dependent hyperpolarization (EDH) in mouse resistance
Yi Shi et al.
PloS one, 9(9), e107787-e107787 (2014-09-24)
The aging gene p66Shc, is an important mediator of oxidative stress-induced vascular dysfunction and disease. In cultured human aortic endothelial cells (HAEC), p66Shc deletion increases endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) bioavailability via protein kinase B.
Rodolfo Urbano et al.
Cell host & microbe, 23(5), 594-606 (2018-05-01)
Staphylococcus aureus is a commensal bacterium that can asymptomatically colonize its host but also causes invasive infections. Quorum sensing regulates S. aureus virulence and the transition from a commensal to a pathogenic organism. However, little is known about how host innate
Massimiliano Marvasi et al.
AMB Express, 4, 42-42 (2014-07-06)
Biofilms in the industrial environment could be problematic. Encased in extracellular polymeric substances, pathogens within biofilms are significantly more resistant to chlorine and other disinfectants. Recent studies suggest that compounds capable of manipulating nitric oxide-mediated signaling in bacteria could induce
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感应染料

一氧化氮 (NO) 是神经元、内皮细胞和免疫系统中的信号转运分子。

Sensor Dyes

Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.

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