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H31859

5-羟基苯并吡咯

Name: 5-羟基苯并吡咯
Brand: ALDRICH

97%

别名:

5-羟基吲哚, 5-羟基苯并吡咯, NSC 87503

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关于此项目

经验公式（希尔记法）:

C₈H₇NO

化学文摘社编号:

1953-54-4

分子量:

133.15

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24895561

EC Number:

217-782-6

Beilstein/REAXYS Number:

112349

MDL number:

MFCD00005677

Assay:

97%

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属性

Quality Level

100

assay

97%

mp

106-108 °C (lit.)

SMILES string

Oc1ccc2[nH]ccc2c1

InChI

1S/C8H7NO/c10-7-1-2-8-6(5-7)3-4-9-8/h1-5,9-10H

InChI key

LMIQERWZRIFWNZ-UHFFFAOYSA-N

说明

Application

用于制备抗肿瘤剂（氧咪唑烷基/氧嘧啶基）苯磺酸酯和微管蛋白抑制剂的反应物
用于制备邻氨基苯甲酸的反应物
用于制备吲哚化合物作为多巴胺D2受体拮抗剂的反应物
用于制备含萘酰亚胺或咔唑的人β-肾上腺素受体配体的反应物
用于制备天然辐射防护剂黑色素的反应物
用于制备 PKCθ 抑制剂5-乙烯基-3-吡啶腈的反应物

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

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Following the excited state relaxation dynamics of indole and 5-hydroxyindole using time-resolved photoelectron spectroscopy.

Ruth Livingstone et al.

The Journal of chemical physics, 135(19), 194307-194307 (2011-11-25)

Time-resolved photoelectron spectroscopy was used to obtain new information about the dynamics of electronic relaxation in gas-phase indole and 5-hydroxyindole following UV excitation with femtosecond laser pulses centred at 249 nm and 273 nm. Our analysis of the data was

Positive modulation of alpha7 nAChR responses in rat hippocampal interneurons to full agonists and the alpha7-selective partial agonists, 4OH-GTS-21 and S 24795.

Gretchen Y López-Hernández et al.

Neuropharmacology, 56(4), 821-830 (2009-08-26)

One approach for the identification of therapeutic agents for Alzheimer's disease has focused on the research of alpha7 nAChR-selective agonists such as the partial agonists 3-(4-hydroxy,2-methoxybenzylidene)anabaseine (4OH-GTS-21) and, more recently, 2-[2-(4-bromophenyl)-2-oxoethyl]-1-methyl pyridinium (S 24795). An alternative approach for targeting alpha7

The L293 residue in transmembrane domain 2 of the 5-HT3A receptor is a molecular determinant of allosteric modulation by 5-hydroxyindole.

Xiang-Qun Hu et al.

Neuropharmacology, 54(8), 1153-1165 (2008-04-26)

Allosteric modulation of ligand-gated ion channels can play important roles in shaping synaptic transmission. The function of the 5-hydroxytryptamine (serotonin) type 3 (5-HT(3)) receptor, a member of the Cys-loop ligand-gated ion channel superfamily, is modulated by a variety of compounds

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全球贸易项目编号

货号	GTIN
H31859-1G	04061833792858