M14935
5-甲氧基-3-吲哚乙酸
98%
别名:
2-(5-Methoxy-3-indolyl)acetic acid
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关于此项目
经验公式（希尔记法）:
C11H11NO3
化学文摘社编号:
分子量:
205.21
Beilstein:
187161
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
质量水平
方案
98%
mp
145-148 °C (dec.) (lit.)
SMILES字符串
COc1ccc2[nH]cc(CC(O)=O)c2c1
InChI
1S/C11H11NO3/c1-15-8-2-3-10-9(5-8)7(6-12-10)4-11(13)14/h2-3,5-6,12H,4H2,1H3,(H,13,14)
InChI key
COCNDHOPIHDTHK-UHFFFAOYSA-N
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应用
- Reactant for preparation of aryloxybenzothiazoles as inhibitors of NO production
- Reactant for preparation of transcription inhibitors of novel Gli1 as antitumor agents
- Reactant for preparation of indole derivatives as NR2B/NMDA receptor antagonists
- Reactant for preparation of indolyl esters and amides related to indomethacin as selective COX-2 inhibitors
- Reactant for preparation of quinoline salicylic acid series of P-selectin antagonists
- Reactant for preparation of prostaglandin D2 receptor antagonists
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
P Li et al.
Biochemical and biophysical research communications, 239(1), 353-356 (1997-11-05)
Endogenous 5-methoxytryptamine (5MT) and its biosynthetic oxidation product, 5-methoxyindole-3-acetic acid (5MIAA), were successfully identified and measured in the retina of the rat and quail by gas chromatography/electron-capture negative ion chemical ionization mass spectrometry (GC/EC-NICI-MS). In the rat retina, diurnal rhythms
V E Ooi et al.
Journal of pineal research, 7(4), 315-324 (1989-01-01)
The effects of late-afternoon injections of melatonin (MEL), 5-methoxytryptamine (MTN), 5-methoxytryptophol (MTOL), and 5-methoxyindole-3-acetic acid (MIAA) on testicular and seminal vesicular histology in the golden hamster were examined. MEL, MTN, and MTOL injections caused a reduction in the diameters of
A A Levchuk et al.
Biulleten' eksperimental'noi biologii i meditsiny, 104(7), 77-79 (1987-07-01)
A comparative study of the effect produced by endogenous carcinogens (p-hydroxyphenyllactic and 5-methoxyindole-3-acetic acids) and their non-cancerogenic analogues on lipid peroxidation in vitro and in vivo was performed. It has been found that cancerogenic tyrosine and serotonin metabolites, unlike their
Satoshi Furukawa et al.
The Journal of toxicological sciences, 30(3), 165-174 (2005-09-06)
Indole-3-acetic acid (IAA), a natural auxin, induces microencephaly in rats exposed to IAA during gestation days (Days) 12-14, corresponding to the early stage of cerebral cortex development. The purpose of this study was to examine the effects of 5 IAA
L A Bondarenko et al.
Biulleten' eksperimental'noi biologii i meditsiny, 110(8), 150-151 (1990-08-01)
5-day morning injections to pubertal male rats of polypeptide epithalamin preparation obtained from cattle epiphysis, in dose of 0.25 mg/100 g body mass induced the increase of serotonin epiphyseal concentration night peak, N-acetylserotonin and melatonin and didn't produce any essential
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