M9775
4-(N-马来酰亚胺)二苯甲酮
别名:
二苯甲酮-4-马来酰亚胺
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关于此项目
经验公式（希尔记法）:
C17H11NO3
化学文摘社编号:
分子量:
277.27
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
InChI
1S/C17H11NO3/c19-15-10-11-16(20)18(15)14-8-6-13(7-9-14)17(21)12-4-2-1-3-5-12/h1-11H
SMILES string
O=C1C=CC(=O)N1c2ccc(cc2)C(=O)c3ccccc3
InChI key
OZIZEXQRIOURIJ-UHFFFAOYSA-N
reaction suitability
reagent type: cross-linking reagent
solubility
chloroform: 50 mg/mL
DMF: soluble
storage temp.
2-8°C
Application
含巯基特异性基团和光敏基团的双异官能化交联剂。通常，初始反应在 pH 为 6.8 (6.5-7.0) 时通过硫醚偶联至含游离巯基的分子。紫外光 (250nm) 照射的过程中通过双自由基激发态发生二次键合。二苯甲酮对 C-H 插入表现出更大的特异性并且在水中比类似试剂更稳定。一般说来，它们附接更有效，因为可对其反复照射；然而可能需要更强的照射。与类似试剂相比，二苯甲酮对还原反应不敏感。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
L Sahlman et al.
The Journal of biological chemistry, 272(47), 29518-29526 (1997-12-31)
Bacterial detoxification of mercuric ion depends on the presence of one or more integral membrane proteins (MerT and/or MerC) whose postulated function is in transport of Hg2+ from a periplasmic Hg2+-binding protein (MerP) to cytoplasmic mercuric reductase. In this study
Takao Inoue et al.
The Journal of biological chemistry, 280(30), 27896-27903 (2005-06-14)
The vacuolar (H+)-ATPases (V-ATPases) are multisubunit complexes responsible for ATP-dependent proton transport across both intracellular and plasma membranes. The V-ATPases are composed of a peripheral domain (V1) that hydrolyzes ATP and an integral domain (V0) that conducts protons. Dissociation of
Yoichiro Arata et al.
Biochemistry, 41(37), 11301-11307 (2002-09-11)
Using a combination of cysteine mutagenesis and covalent cross-linking, we have identified subunits in close proximity to specific sites within subunit B of the vacuolar (H(+))-ATPase (V-ATPase) of yeast. Unique cysteine residues were introduced into subunit B by site-directed mutagenesis
T Tao et al.
Archives of biochemistry and biophysics, 240(2), 627-634 (1985-08-01)
The site-specific photocrosslinker, benzophenone-4-maleimide, was used to label G-actin specifically at Cys-374, the penultimate residue from the C terminus. The resultant BP-G-actin was polymerized to form BP-F-actin, and both forms of actin were irradiated to activate the benzophenone moiety. We
J F Clémence et al.
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To attain light-dependent functionalization of biocompatible materials, a photolabel-derivatized, bioactive laminin fragment has been synthesized, chemically characterized, and photoimmobilized. Covalent high-resolution patterning of the laminin fragment CDPGYIGSR to hydroxylated fluorinated ethylene propylene (FEP-OH), poly(vinyl alcohol), and glycophase glass has been
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