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Merck
CN

N1280

去甲氯米帕明 盐酸盐

≥98% (TLC), powder

别名:

N-去甲氯丙咪嗪

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关于此项目

经验公式(希尔记法):
C18H21ClN2 · HCl
化学文摘社编号:
分子量:
337.29
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
≥98% (TLC)
Form:
powder
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InChI key

KMDDAZOLOSKTKZ-UHFFFAOYSA-N

SMILES string

Cl.CNCCCN1c2ccccc2CCc3ccc(Cl)cc13

InChI

1S/C18H21ClN2.ClH/c1-20-11-4-12-21-17-6-3-2-5-14(17)7-8-15-9-10-16(19)13-18(15)21;/h2-3,5-6,9-10,13,20H,4,7-8,11-12H2,1H3;1H

assay

≥98% (TLC)

form

powder

color

white to yellow

Quality Level

Biochem/physiol Actions

三环抗抑郁剂;氯米帕明的活性代谢物,优先阻断去甲肾上腺素转运体。

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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S Härtter et al.
Psychopharmacology, 117(2), 149-153 (1995-01-01)
The selective serotonin reuptake inhibitor fluvoxamine interferes with the metabolism of tricyclic antidepressants. The present investigation was set out to characterize these interactions in vitro using rat liver microsomes and in vivo by analysing levels of clomipramine and metabolites in
K Fujita et al.
European journal of pharmacology, 204(3), 227-233 (1991-11-12)
When rats received a single i.p. injection of clomipramine (20 mg/kg), clomipramine and desmethylclomipramine were rapidly distributed into the brain and their concentrations were markedly higher in the brain than in the serum, while the concentration of the metabolite in
P O Feet et al.
Acta psychiatrica Scandinavica, 89(4), 230-234 (1994-04-01)
A double-blind 12 week trial was undertaken to compare the effects of clomipramine + dixyrazine with clomipramine + placebo in the treatment of panic disorder with or without agoraphobia. Of 45 patients included (21 dixyrazine, 24 placebo), 16 dropped out
J N King et al.
American journal of veterinary research, 61(1), 80-85 (2000-01-12)
To determine pharmacokinetics of clomipramine and its principle metabolite (desmethylclomipramine) in the plasma of dogs following single-dose and repeated-dose oral administration at various dosages. 9 male and 9 female Beagles. Clomipramine was administered orally at a dose of 1, 2
Clinical pharmacology and therapeutics, 66(2), 152-165 (1999-08-25)
To examine the problems of establishing dose-effect and concentration-effect relationships of antidepressant therapy with clomipramine. This randomized double-blind study compared five fixed doses of clomipramine hydrochloride: 25, 50, 75, 125, and 200 mg/day in hospitalized or day patients at nine

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