N17602
5-硝基吲哚
98%
别名:
NSC 520594
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关于此项目
经验公式（希尔记法）:
C8H6N2O2
化学文摘社编号:
分子量:
162.15
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
228-153-0
Beilstein/REAXYS Number:
383777
MDL number:
Assay:
98%
Form:
powder
InChI
1S/C8H6N2O2/c11-10(12)7-1-2-8-6(5-7)3-4-9-8/h1-5,9H
InChI key
OZFPSOBLQZPIAV-UHFFFAOYSA-N
SMILES string
[O-][N+](=O)c1ccc2[nH]ccc2c1
assay
98%
form
powder
Quality Level
Application
作为以下制备反应的反应物：
- 具有药物活性的 2-氧代-1-吡咯烷类似物
- 色氨酸双加氧酶抑制剂吡啶基-乙烯基-吲哚类化合物可作为潜在的抗癌免疫调节剂
- 蛋白激酶抑制剂和抗增殖剂
- 代谢型谷氨酸受体4（mGlu4）的正变构调节剂。
- 抗真菌剂
- 大麻素1型受体（CB1）拮抗剂
- 潜在抗癌剂
- 潜在的抗血管药
- 选择性抗白血病药
- 抗人类免疫缺陷病毒亚型1（HIV-1）的药物
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Wengen Ouyang et al.
Journal of chemical theory and computation, 16(1), 666-676 (2019-12-10)
The importance of many-body dispersion effects in layered materials subjected to high external loads is evaluated. State-of-the-art many-body dispersion density functional theory calculations performed for graphite, hexagonal boron nitride, and their heterostructures were used to fit the parameters of a
D Loakes et al.
Journal of molecular biology, 270(3), 426-435 (1997-07-18)
The nature of DNA containing the deoxyribosyl derivative of 5-nitroindole has been investigated. 5-Nitroindole has been shown to give good stability when present in duplexes opposite natural bases, with only slightly reduced melting temperatures. However, enhanced stability occurs when it
M Dubin et al.
Biochemical pharmacology, 48(7), 1483-1492 (1994-10-07)
5-Nitroindole (NI), a mutagenic nitroarene, was assayed for cytotoxic effects on rat hepatocytes. After incubation with 25-100 microM NI, the adenylate energy charge of the hepatocytes decreased significantly as a result of the decrease in ATP and the increase in
David Loakes et al.
Journal of the American Chemical Society, 131(41), 14827-14837 (2009-09-26)
Hydrophobic base analogues (HBAs) have shown great promise for the expansion of the chemical and coding potential of nucleic acids but are generally poor polymerase substrates. While extensive synthetic efforts have yielded examples of HBAs with favorable substrate properties, their
José Gallego et al.
Nucleic acids research, 35(9), 2904-2912 (2007-04-18)
Universal bases hybridize with all other natural DNA or RNA bases, and have applications in PCR and sequencing. We have analysed by nuclear magnetic resonance spectroscopy the structure and dynamics of three DNA oligonucleotides containing the universal base analogues 5-nitroindole
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