N3386
D -(+)-新蝶呤
≥97.5% (sum of enantiomers, HPLC)
别名:
D-赤型新蝶呤
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关于此项目
经验公式（希尔记法）:
C9H11N5O4
化学文摘社编号:
分子量:
253.21
UNSPSC Code:
12352005
NACRES:
NA.22
PubChem Substance ID:
EC Number:
217-924-7
Beilstein/REAXYS Number:
89070
MDL number:
Assay:
≥97.5% (sum of enantiomers, HPLC)
Form:
powder
InChI key
BMQYVXCPAOLZOK-XINAWCOVSA-N
InChI
1S/C9H11N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h1,4,6,15-17H,2H2,(H3,10,11,13,14,18)/t4-,6+/m1/s1
SMILES string
Nc1nc(O)c2nc(cnc2n1)[C@H](O)[C@H](O)CO
assay
≥97.5% (sum of enantiomers, HPLC)
form
powder
storage temp.
2-8°C
Quality Level
General description
D-（+）-新蝶呤是一种蝶啶衍生物，天然存在于盘基网柄菌中。 其在癌症患者的尿液中被发现大量存在。
Application
在评估乳腺癌细胞中NADPH氧化酶产生活性氧（ROS）的能力时，D-（+）-新蝶呤可被用作NADPH氧化酶的抑制剂。[NADPH =烟酰胺腺嘌呤二核苷酸磷酸]
Biochem/physiol Actions
喋呤辅因子；BH4（四氢生物蝶呤）的前体。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Pteridine analysis in urine by capillary electrophoresis using laser-induced fluorescence detection.
Han F, et al.
Analytical Chemistry, 71(7), 1265-1269 (1999)
Dictyopterin, 6-(d-threo-1,2-dihydroxypropyl)-pterin, a new natural isomer of L-biopterin.
Klein R, et al.
European Journal of Biochemistry, 187(3), 665-669 (1990)
Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells.
Ma S, et al.
Cell Death & Disease, 7(7), e2307-e2307 (2016)
O B Federiakina et al.
Klinicheskaia laboratornaia diagnostika, (3)(3), 13-15 (2013-07-03)
The study had a purpose to evaluate the level of serum neopterin in the process of adaptation of healthy newborns to postnatal life. The dynamic clinical monitoring and comparative analysis was applied to determine the level of neopterin in serum
Bohuslav Melichar et al.
Anticancer research, 32(9), 4077-4084 (2012-09-21)
To investigate the relation between intima-media thickness (IMT) and laboratory parameters of atherosclerosis risk in patients with breast carcinoma. IMT and a panel of laboratory parameters associated with the risk of atherosclerosis were studied in 192 patients with histologically-verified breast
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