InChI key
LFSXCDWNBUNEEM-UHFFFAOYSA-N
InChI
1S/C8H6N2/c1-2-4-8-6-10-9-5-7(8)3-1/h1-6H
SMILES string
c1ccc2cnncc2c1
assay
98%
form
crystals
bp
189 °C/29 mmHg (lit.)
mp
89-92 °C (lit.)
storage temp.
2-8°C
Quality Level
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signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 3 - Muta. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Panayiotis A Procopiou et al.
Journal of medicinal chemistry, 54(7), 2183-2195 (2011-03-09)
A series of potent phthalazinone-based human H(1) and H(3) bivalent histamine receptor antagonists, suitable for intranasal administration for the potential treatment of allergic rhinitis, were identified. Blockade of H(3) receptors is thought to improve efficacy on nasal congestion, a symptom
R S K Vijayan et al.
Journal of molecular graphics & modelling, 27(3), 286-298 (2008-06-21)
Given the heterogeneity of GABA(A) receptor, the pharmacological significance of identifying subtype selective modulators is increasingly being recognized. Thus, drugs selective for GABA(A) alpha(3) receptors are expected to display fewer side effects than the drugs presently in clinical use. Hence
Kebin Li et al.
Analytical chemistry, 80(13), 4945-4950 (2008-05-30)
Arrays of Au nanowells (NWs) were fabricated by electron-beam lithography (EBL) and characterized by surface plasmon resonance (SPR) and surface-enhanced Raman scattering (SERS). It is revealed that these Au NW arrays exhibit multiple SP resonances that can be tuned by
Hyungchul Kim et al.
International journal of pharmaceutics, 377(1-2), 105-111 (2009-05-26)
Investigation of the use of solution NMR spectroscopy to determine the effect of organic solvents on chemical shift changes in bases on addition of acids is reported. This information can be useful in the evaluation of solvents and counterion selection
Brad Herberich et al.
Journal of medicinal chemistry, 51(20), 6271-6279 (2008-09-27)
Investigations into the structure-activity relationships (SAR) of a series of phthalazine-based inhibitors of p38 are described. These efforts originated from quinazoline 1 and through rational design led to the development of a series of orally bioavailable, potent, and selective inhibitors.
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