P38706
酞嗪
98%
别名:
β-苯并二氮杂卓, 2,3-二氮杂萘, 2,3-苯并二氮杂卓, 苯并[d]哒嗪
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关于此项目
经验公式（希尔记法）:
C8H6N2
化学文摘社编号:
分子量:
130.15
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
205-963-2
MDL number:
产品名称
酞嗪, 98%
InChI key
LFSXCDWNBUNEEM-UHFFFAOYSA-N
InChI
1S/C8H6N2/c1-2-4-8-6-10-9-5-7(8)3-1/h1-6H
SMILES string
c1ccc2cnncc2c1
assay
98%
form
crystals
bp
189 °C/29 mmHg (lit.)
mp
89-92 °C (lit.)
storage temp.
2-8°C
Quality Level
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signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 3 - Muta. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Michał Achmatowicz et al.
The Journal of organic chemistry, 74(2), 795-809 (2008-12-18)
p38 MAP kinase inhibitors have attracted considerable interest as potential agents for the treatment of inflammatory diseases. Herein, we describe a concise and efficient synthesis of inhibitor 1 that is based on a phthalazine scaffold. Highlights of our approach include
Fadi M Awadallah et al.
European journal of medicinal chemistry, 52, 14-21 (2012-03-24)
New phthalazine-based vasodilators were synthesized through the chloroacylation of the starting compound 1-hydrazinophthalazine 4 to give the two key intermediates 5 and 7. These intermediates were used to alkylate various cyclic amines to furnish the final compounds 6a-h and 8a-h.
Hyungchul Kim et al.
International journal of pharmaceutics, 377(1-2), 105-111 (2009-05-26)
Investigation of the use of solution NMR spectroscopy to determine the effect of organic solvents on chemical shift changes in bases on addition of acids is reported. This information can be useful in the evaluation of solvents and counterion selection
Manuel Sánchez-Moreno et al.
Journal of medicinal chemistry, 55(22), 9900-9913 (2012-10-10)
A series of new phthalazine derivatives 1-4 containing imidazole rings were prepared. The monoalkylamino substituted derivatives 2 and 4 were more active in vitro against T. cruzi and less toxic against Vero cells than both their disubstituted analogues and the
Jin Sung Kim et al.
Bioorganic & medicinal chemistry, 16(8), 4545-4550 (2008-03-07)
Studies on antitumor heterocyclic quinones containing nitrogens revealed that the number and position of nitrogens on the heterocyclic ring have significance on cytotoxicity of quinones. In our continuous effort to find more cytotoxic quinone compounds, we designed triazolophthalazine analogues in
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