S154
墨蝶呤
solid
别名:
S-(-)-2-氨基-7,8-二氢-6-(2-羟基-1-氧代丙基)-4(1H)-蝶啶酮, L-Sepiapterin
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关于此项目
经验公式（希尔记法）:
C9H11N5O3
化学文摘社编号:
分子量:
237.22
MDL编号:
UNSPSC代码:
12352005
PubChem化学物质编号:
NACRES:
NA.22
表单
solid
颜色
yellow
溶解性
DMSO: 27 mg/mL
0.1 M NaOH: 9.8 mg/mL
εmax
6170 at 409 nm in 0.1 M HCl
7410 at 271 nm in 0.1 M HCl at 1%
储存温度
−20°C
SMILES字符串
C[C@H](O)C(=O)C1=NC2=C(NC1)NC(N)=NC2=O
InChI
1S/C9H11N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3,15H,2H2,1H3,(H4,10,11,13,14,17)/t3-/m0/s1
InChI key
VPVOXUSPXFPWBN-VKHMYHEASA-N
基因信息
human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
一般描述
墨蝶呤是一种蝶啶衍生物，是四氢生物蝶呤（BH4）的一种稳定前体。它是在黑腹果蝇和柠檬家蚕突变体（家蚕）的棕褐色突变体中发现的一种黄色色素。
应用
墨蝶蛉可用于诱导双链DNA中的序列特异性光损伤。
生化/生理作用
一氧化氮合成酶辅因子；细胞内转化为四氢-生物蝶呤，刺激一氧化氮的生成。
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Aidamalia Vargas-Lowman et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(38), 19046-19054 (2019-09-06)
Naturalists have been fascinated for centuries by animal colors and color patterns. While widely studied at the adult stage, we know little about color patterns in the embryo. Here, we study a trait consisting of coloration that is specific to
R Lelchuk et al.
The Journal of pharmacology and experimental therapeutics, 262(3), 1220-1224 (1992-09-01)
Human megakaryoblastic cells (Meg-01) were found to possess constitutive and express inducible nitric oxide (NO) synthase activities. The constitutive NO synthase was Ca+(+)- and NADPH-dependent, as is the NO synthase found previously in human platelets. Stimulation of Meg-01 cells by
Surawee Chuaiphichai et al.
British journal of pharmacology, 174(8), 657-671 (2017-01-28)
The cofactor tetrahydrobiopterin (BH4) is a critical regulator of endothelial NOS (eNOS) function, eNOS-derived NO and ROS signalling in vascular physiology. To determine the physiological requirement for de novo endothelial cell BH4 synthesis for the vasomotor function of resistance arteries
G Schoedon et al.
European journal of biochemistry, 213(2), 833-839 (1993-04-15)
Nitric oxide is a recently discovered biomolecule with a broad range of actions. The present study investigated the regulation of nitric oxide synthase activity by dexamethasone and the cofactor tetrahydrobiopterin in murine macrophages. The influence of the tetrahydrobiopterin biosynthesis inhibitors
Ariel Rodríguez et al.
BMC genomics, 21(1), 301-301 (2020-04-16)
Animal coloration is usually an adaptive attribute, under strong local selection pressures and often diversified among species or populations. The strawberry poison frog (Oophaga pumilio) shows an impressive array of color morphs across its distribution in Central America. Here we
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