T7650
替拉曲可
≥90%
别名:
替拉曲考
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关于此项目
经验公式（希尔记法）:
C14H9I3O4
化学文摘社编号:
分子量:
621.93
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
200-086-1
MDL number:
Assay:
≥90%
Form:
powder
InChI key
UOWZUVNAGUAEQC-UHFFFAOYSA-N
InChI
1S/C14H9I3O4/c15-9-6-8(1-2-12(9)18)21-14-10(16)3-7(4-11(14)17)5-13(19)20/h1-4,6,18H,5H2,(H,19,20)
SMILES string
OC(=O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1
assay
≥90%
form
powder
storage temp.
−20°C
Quality Level
Gene Information
human ... THRA(7067), THRB(7068)
rat ... Thra(81812), Thrb(24831)
Application
- 甲状腺激素研究：研究3,3′,5-三碘甲腺乙酸对MCT8缺陷患者的外周和神经发育影响，说明它的甲状腺相关发育疾病的治疗潜力(Unsal and Hayran, 2024)。
- 神经疾病治疗：研究用3,3′,5-三碘甲腺乙酸解决Allan-Herndon-Dudley综合征模拟大脑类器官的T3摄入和作用异常，为治疗大脑特异性甲状腺激素转运异常提供依据(Salas-Lucia et al., 2024)。
- 抗病毒治疗的药物发展：Tiratricol是3,3′,5-三碘甲腺乙酸的衍生物，研究发现它可通过靶向依赖病毒RNA的RNA聚合酶抑制黄热病毒复制，显示抗病毒药物开发潜力(Ren et al., 2023)。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
13 - Non Combustible Solids
wgk
WGK 3
Leandro Martínez et al.
Journal of medicinal chemistry, 49(1), 23-26 (2006-01-06)
Steered molecular dynamics simulations of ligand dissociation from Thyroid hormone receptors indicate that dissociation is favored via rearrangements in a mobile part of the LBD comprising H3, the loop between H1 and H2, and nearby beta-sheets, contrary to current models
Rie Anzai et al.
Thyroid : official journal of the American Thyroid Association, 22(10), 1069-1075 (2012-09-06)
The effectiveness of short-term 3,5,3'-triiodothyroacetic acid (TRIAC) therapy for the treatment of hyperthyroidism caused by thyroid hormone resistance (RTH) has been documented. Here, we report a 3-year course of TRIAC therapy in an RTH boy, with a quantitative evaluation of
Wim Klootwijk et al.
Endocrinology, 152(8), 3259-3267 (2011-06-10)
Thyroid hormone (TH) is important for metamorphosis in many species, including the cephalochordate Branchiostoma floridae, a marine invertebrate (amphioxus) living in warmer coastal areas. Branchiostoma expresses a TH receptor, which is activated by 3,3',5-triiodothyroacetic acid (TA(3)) but not by T(3).
Mathilde Paris et al.
Integrative and comparative biology, 50(1), 63-74 (2011-05-12)
Thyroid hormones (THs), and more precisely the 3,3',5-triiodo-l-thyronine (T(3)) acetic derivative 3,3',5-triiodothyroacetic acid (TRIAC), have been shown to activate metamorphosis in amphioxus. However, it remains unknown whether TRIAC is endogenously synthesized in amphioxus and more generally whether an active TH
Christopher J Ryerson et al.
Journal of pain and symptom management, 43(4), 771-782 (2012-01-31)
Little is known about the treatment and correlates of dyspnea in idiopathic pulmonary fibrosis (IPF). The objective of this systematic review was to summarize the literature regarding the treatment and correlates of dyspnea in IPF. MEDLINE, EMBASE, and all Evidence-Based
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