A1606
4-乙酰氨基安替比林
97%
别名:
4-Acetylaminophenazone, N-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)acetamide, N-Antipyrinylacetamide, NSC 331807
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关于此项目
经验公式（希尔记法）:
C13H15N3O2
化学文摘社编号:
分子量:
245.28
EC Number:
201-457-0
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
234585
MDL number:
InChI key
OIAGWXKSCXPNNZ-UHFFFAOYSA-N
InChI
1S/C13H15N3O2/c1-9-12(14-10(2)17)13(18)16(15(9)3)11-7-5-4-6-8-11/h4-8H,1-3H3,(H,14,17)
SMILES string
CN1N(C(=O)C(NC(C)=O)=C1C)c2ccccc2
assay
97%
mp
200-203 °C (lit.)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Further metabolism of 4-acetylaminoantipyrine, the major metabolite of aminopyrine, in rats.
T Tanaka et al.
Chemical & pharmaceutical bulletin, 35(8), 3519-3522 (1987-08-01)
S C Pierre et al.
British journal of pharmacology, 151(4), 494-503 (2007-04-17)
Dipyrone is a potent analgesic drug that has been demonstrated to inhibit cyclooxygenase (COX). In contrast to classical COX-inhibitors, such as aspirin-like drugs, dipyrone has no anti-inflammatory effect and a low gastrointestinal toxicity, indicating a different mode of action. Here
G Heinemeyer et al.
European journal of clinical pharmacology, 45(5), 445-450 (1993-01-01)
We have studied the clearance of monomethylaminoantipyrine (MMAAP), the pharmacologically active form of metamizol, in 46 patients in surgical intensive care with different degrees of renal dysfunction. In 23 patients without any renal impairment, mean clearance was 2.8 ml.min-1 x
E Neddermann et al.
European journal of drug metabolism and pharmacokinetics, 13(2), 105-111 (1988-04-01)
Metabolites of dipyrone have been determined in the saliva of 18 volunteers following the oral intake of 0.5 g, 1.0 g, 1.5 g, 2.0 g and 2.5 g dipyrone. High concentrations were measured for N-methyl-aminoantipyrine (MAA), the other analgetic active
Y Matzner et al.
European journal of clinical investigation, 14(6), 440-443 (1984-12-01)
Dipyrone metabolites 4-methylaminoantipyrine (MAA) and 4-formylaminoantipyrine (FAA) as well as acetylsalicylic acid inhibited neutrophil migration toward zymosan-activated serum. Inhibition was maximal (76.8 +/- 19.0; 79.2 +/- 12.5 and 80.0 +/- 4.4%, respectively, P less than 0.003) when suboptimal concentrations (0.3%)
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