A54601
2-异硫脲 二氢溴酸
99%
别名:
2-(2-Aminoethyl)-2-thiopseudourea dihydrobromide, AET, S-(2-Aminoethyl)isothiouronium bromide hydrobromide
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关于此项目
线性分子式:
NH2CH2CH2SC(=NH)NH2 · 2HBr
化学文摘社编号:
分子量:
281.01
EC Number:
200-257-0
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
3911163
MDL number:
InChI key
XDVMCVGTDUKDHL-UHFFFAOYSA-N
InChI
1S/C3H9N3S.2BrH/c4-1-2-7-3(5)6;;/h1-2,4H2,(H3,5,6);2*1H
SMILES string
Br[H].Br[H].NCCSC(N)=N
assay
99%
mp
190-196 °C (lit.)
Application
Has radioprotective activity against x-rays.
Biochem/physiol Actions
Inhibits constitutive and inducible NOS.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
S K Basu et al.
Indian journal of experimental biology, 31(10), 837-842 (1993-10-01)
Radioprotective effectiveness has been evaluated by 30 day survival studies and protection to bone-marrow cells in mice after radiation exposure and this has been further established by 24 hr deoxycytidine excretion in urine of rats following 5 Gy whole body
S K Basu et al.
Indian journal of experimental biology, 30(6), 478-481 (1992-06-01)
Differential radioprotection between normal tissues and carcinoma was observed in C3H/J mice treated with a combination of 5-hydroxy L-tryptophan (5-HTP, 100 mg/kg) and 2-aminoethylisothiuronium bromide hydrobromide (AET, 20 mg/kg). Protection to normal tissues was judged by LD50(30) and by radiation
A Kis et al.
Journal of molecular and cellular cardiology, 31(6), 1229-1241 (1999-06-18)
Right ventricular pacing in lightly anaesthetized dogs (4x5 min periods at a pacing rate of 220 beats/min) protects against the consequences of coronary artery occlusion when this is initiated 24 h after the pacing stimulus. The main purpose of the
Ni Ni Tun et al.
Plant & cell physiology, 47(3), 346-354 (2006-01-18)
In this study, we examined the regulation by putrescine, spermidine and spermine of nitric oxide (NO) biosynthesis in Arabidopsis thaliana seedlings. Using a fluorimetric method employing the cell-impermeable NO-binding dye diaminorhodamine-4M (DAR-4M), we observed that the polyamines (PAs) spermidine and
Y Gundersen et al.
Shock (Augusta, Ga.), 8(5), 368-372 (1997-11-15)
Endotoxin has profound effects on nitric oxide (NO) production, and considerable controversies exist as to whether these alterations are beneficial or deleterious. Increased mortality has been reported from nonselective inhibition of NO synthase. Results from selective inhibition of the inducible
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