A54601
2-异硫脲 二氢溴酸
99%
别名:
2-(2-Aminoethyl)-2-thiopseudourea dihydrobromide, AET, S-(2-Aminoethyl)isothiouronium bromide hydrobromide
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关于此项目
线性分子式:
NH2CH2CH2SC(=NH)NH2 · 2HBr
化学文摘社编号:
分子量:
281.01
Beilstein:
3911163
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
方案
99%
mp
190-196 °C (lit.)
SMILES字符串
Br[H].Br[H].NCCSC(N)=N
InChI
1S/C3H9N3S.2BrH/c4-1-2-7-3(5)6;;/h1-2,4H2,(H3,5,6);2*1H
InChI key
XDVMCVGTDUKDHL-UHFFFAOYSA-N
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应用
Has radioprotective activity against x-rays.
生化/生理作用
Inhibits constitutive and inducible NOS.
警示用语:
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
S K Basu et al.
Indian journal of experimental biology, 31(10), 837-842 (1993-10-01)
Radioprotective effectiveness has been evaluated by 30 day survival studies and protection to bone-marrow cells in mice after radiation exposure and this has been further established by 24 hr deoxycytidine excretion in urine of rats following 5 Gy whole body
Y Gundersen et al.
The European journal of surgery = Acta chirurgica, 165(12), 1167-1174 (2000-01-15)
To examine the effects of the inducible nitric oxide synthase inhibitor aminoethyl-isothiourea (AE-ITU) on haemodynamic measurements, and correlate these with hepatic morphology and function in a porcine model of endotoxaemia. Experimental study. 15 juvenile pigs. Flow probes were placed around
O A Strand et al.
Scandinavian journal of clinical and laboratory investigation, 57(2), 105-109 (1997-04-01)
The effect of inhibiting nitric oxide (NO) synthesis during sepsis was studied in a caecal perforation model on Wistar rats. This model induces severe abdominal sepsis with a 48-h mortality > 90% in untreated animals. The survival time in hours
S K Basu et al.
Indian journal of experimental biology, 30(6), 478-481 (1992-06-01)
Differential radioprotection between normal tissues and carcinoma was observed in C3H/J mice treated with a combination of 5-hydroxy L-tryptophan (5-HTP, 100 mg/kg) and 2-aminoethylisothiuronium bromide hydrobromide (AET, 20 mg/kg). Protection to normal tissues was judged by LD50(30) and by radiation
Ni Ni Tun et al.
Plant & cell physiology, 47(3), 346-354 (2006-01-18)
In this study, we examined the regulation by putrescine, spermidine and spermine of nitric oxide (NO) biosynthesis in Arabidopsis thaliana seedlings. Using a fluorimetric method employing the cell-impermeable NO-binding dye diaminorhodamine-4M (DAR-4M), we observed that the polyamines (PAs) spermidine and
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