InChI key
SSMIFVHARFVINF-UHFFFAOYSA-N
InChI
1S/C12H8N2O2/c13-9-5-4-8-10-6(9)2-1-3-7(10)11(15)14-12(8)16/h1-5H,13H2,(H,14,15,16)
SMILES string
Nc1ccc2C(=O)NC(=O)c3cccc1c23
assay
96%
density
1.105 g/mL at 25 °C (lit.)
Kenjiro Hanaoka et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 16(2), 568-572 (2009-11-18)
Fluorescence imaging is a powerful tool for the visualization of biological molecules in living cells, tissue slices, and whole bodies, and is important for elucidating biological phenomena. Furthermore, zinc (Zn(2+)) is the second most abundant heavy metal ion in the
Raman Parkesh et al.
Organic & biomolecular chemistry, 5(2), 310-317 (2007-01-06)
The design and synthesis of two novel fluorescent sensors based on the photoinduced electron transfer (PET) concept, and , for the detection of zinc under competitive media is described. These sensors are based on the 4-amino-1,8-naphthalimide fluorophore, which has an
J A Muñoz-Gámez et al.
Cancer letters, 301(1), 47-56 (2010-11-26)
The purpose of this study was to investigate whether PARP-1 inhibition sensitizes human liver cancer cell lines to doxorubicin treatment. Both the addition of PARP-1 inhibitor (ANI) and depletion by means of stable siRNA significantly enhanced the growth inhibition induced
Camille Godon et al.
Nucleic acids research, 36(13), 4454-4464 (2008-07-08)
The consequences of PARP-1 disruption or inhibition on DNA single-strand break repair (SSBR) and radio-induced lethality were determined in synchronized, isogenic HeLa cells stably silenced or not for poly(ADP-ribose) polymerase-1 (PARP-1) (PARP-1(KD)) or XRCC1 (XRCC1(KD)). PARP-1 inhibition prevented XRCC1-YFP recruitment
Emma B Veale et al.
The Journal of organic chemistry, 75(16), 5513-5525 (2010-08-14)
The synthesis and characterization of three bis-1,8-naphthalimide-containing Tröger's bases 1-3, formed from the corresponding 4-amino-1,8-naphthalimide precursors 7-9 in a single step, is described. The photophysical investigation of 1-3 and 7-9 was carried out in various organic solvents as well as
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