A77806
4-氨基吡唑并[3,4-d]嘧啶
98%
别名:
1H-Pyrazolo[3,4-d]pyrimidine-4-ylamine, 4-Amino-1H-pyrazolo[3,4-d]pyrimidine
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关于此项目
经验公式（希尔记法）:
C5H5N5
化学文摘社编号:
分子量:
135.13
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
219-174-6
MDL number:
Assay:
98%
Form:
powder
InChI
1S/C5H5N5/c6-4-3-1-9-10-5(3)8-2-7-4/h1-2H,(H3,6,7,8,9,10)
InChI key
LHCPRYRLDOSKHK-UHFFFAOYSA-N
SMILES string
Nc1ncnc2[nH]ncc12
assay
98%
form
powder
mp
>325 °C (lit.)
Application
可显著降低大鼠体内的血清胆固醇。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
B Rodrigues et al.
Canadian journal of physiology and pharmacology, 70(9), 1271-1279 (1992-09-01)
The objective of this investigation was to test the hypothesis that the diabetes-induced reduction in lipoprotein lipase activity in cardiac myocytes may be due to hypertriglyceridemia. Administration of 4-aminopyrazolopyrimidine (50 mg/kg) to control rats for 24 h reduced plasma triacylglycerol
J F Goodrum
Journal of neurochemistry, 60(4), 1564-1566 (1993-04-01)
Following a nerve crush, cholesterol from degenerating myelin is retained within the nerve and reutilized for new myelin synthesis during nerve regeneration, apparently via a lipoprotein-mediated process. Because at least some serum components have access to the endoneurium of injured
R F Aten et al.
Endocrinology, 135(2), 533-539 (1994-08-01)
Reactive oxygen species, such as superoxide, hydrogen peroxide, and lipid peroxides, impair luteal function. Vitamin E, a lipophilic antioxidant vitamin, provides a major avenue of protection by scavenging free radicals and terminating lipid peroxidation. We previously showed that ovarian vitamin
T Minami et al.
International journal of pancreatology : official journal of the International Association of Pancreatology, 13(3), 169-174 (1993-06-01)
A single dose of 4-aminopyrazolo(3,4-d) pyrimidine (4APP), an adenine analog, was orally administered at various concentrations of groups of mice and after 24 h, the plasma-alpha-amylase activity and cholesterol levels had significantly decreased in a dose-dependent manner. There was no
K R Feingold et al.
Infection and immunity, 63(5), 2041-2046 (1995-05-01)
Previous studies have shown that endotoxin (lipopolysaccharide [LPS])-induced death can be prevented by preincubating LPS with lipoproteins in vitro or by infusing large quantities of lipids into animals prior to LPS administration. In the present study we determined whether physiological
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