A9584
N-乙酰氧基-N-乙酰基-4-氯苯磺酰胺
≥98%
别名:
O-乙酰基-N-(4-氯苯基磺酰)乙酰羟肟酸
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关于此项目
经验公式（希尔记法）:
C10H10ClNO5S
化学文摘社编号:
分子量:
291.71
PubChem Substance ID:
UNSPSC Code:
12352100
Beilstein/REAXYS Number:
5821854
MDL number:
assay
≥98%
form
flakes
storage temp.
2-8°C
SMILES string
CC(=O)ON(C(C)=O)S(=O)(=O)c1ccc(Cl)cc1
InChI
1S/C10H10ClNO5S/c1-7(13)12(17-8(2)14)18(15,16)10-5-3-9(11)4-6-10/h3-6H,1-2H3
InChI key
GWYBSWWLKXEDLB-UHFFFAOYSA-N
Application
在中性溶液中释放硝酰基 (HNO) 的化合物
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
J M Fukuto et al.
Biochemical and biophysical research communications, 187(3), 1367-1373 (1992-09-30)
N,O-Diacylated-N-hydroxyarylsulfonamides are capable of slowly releasing nitroxyl (HNO) by simple, non-enzymatic hydrolysis in Krebs solution at 37 degrees C. Release of nitric oxide (NO) was not seen. These compounds were also found to elicit vasorelaxation in rabbit thoracic aorta in
M J Lee et al.
Journal of medicinal chemistry, 35(20), 3648-3652 (1992-10-02)
In the preceding paper, analogs of chlorpropamide with an OMe substituent on the sulfonamide nitrogen were shown to inhibit aldehyde dehydrogenase (AlDH), and it was postulated that these compounds were bioactivated by O-demethylation to release nitroxyl (HN = O, nitrosyl