B8750
1-苄基吲哚-3-甲醛
别名:
1-Benzyl-3-formylindole, NSC 95434
表单
solid
储存温度
−20°C
SMILES字符串
O=Cc1cn(Cc2ccccc2)c3ccccc13
InChI
1S/C16H13NO/c18-12-14-11-17(10-13-6-2-1-3-7-13)16-9-5-4-8-15(14)16/h1-9,11-12H,10H2
InChI key
OXCITQLDOUGVRZ-UHFFFAOYSA-N
应用
- reactant in preparation of inhibitor of the C-terminal domain of RNA polymerase II
- reactant in Nazarov type electrocyclization
- reactant in preparation inhibitors of Bcl-2 family of proteins
- reactant for Mannich type coupling with aldehydes and secondary amines
Atlan, V.; et al.
Chemical Communications (Cambridge, England), 7, 918-918 (2003)
Ritesh Singh et al.
Organic & biomolecular chemistry, 9(13), 4782-4790 (2011-02-25)
An easy, efficient and concise approach to tetrahydrofluorene [6,5,6]ABC tricyclic core embedded new polycycles has been achieved under relatively mild and catalytic Nazarov type electrocyclization conditions, using 2 mol% of Sc(OTf)(3) in anhydrous DCM (dichloromethane) at room temperature, with high
Bingcheng Zhou et al.
ChemMedChem, 6(5), 904-921 (2011-04-27)
A class of compounds with a common thiazolo[3,2-a]pyrimidinone motif has been developed as general inhibitors of Bcl-2 family proteins. The lead compound was originally identified in a random screening of a small compound library using a fluorescence polarization-based competitive binding
Shuhong Wu et al.
Journal of medicinal chemistry, 54(8), 2668-2679 (2011-03-30)
To optimize the antitumor activity of oncrasin-1, a small molecule RNA polymerase II inhibitor, we evaluated 69 oncrasin-1 analogues for their cytotoxic activity against normal human epithelial cells and K-Ras mutant tumor cells. About 40 of those compounds were as
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