C011
顺式-2-甲基-5-三甲基铵甲基-1,3-氧硫杂环戊烷碘化物
别名:
OXA-22
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关于此项目
经验公式（希尔记法）:
C8H18INOS
化学文摘社编号:
分子量:
303.20
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
InChI key
TWNAKQKXXMGYQT-WSZWBAFRSA-M
SMILES string
[I-].C[C@H]1O[C@H](CS1)C[N+](C)(C)C
InChI
1S/C8H18NOS.HI/c1-7-10-8(6-11-7)5-9(2,3)4;/h7-8H,5-6H2,1-4H3;1H/q+1;/p-1/t7-,8-;/m0./s1
color
yellow
solubility
H2O: soluble, methanol: soluble
Gene Information
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
Biochem/physiol Actions
强效毒蕈碱型乙酰胆碱受体激动剂。
Disclaimer
感光性
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
P Angeli et al.
British journal of pharmacology, 85(4), 783-786 (1985-08-01)
The efficacy and affinity of nine pentatomic cyclic muscarinic agonists were determined on the guinea-pig ileum, according to the method of Furchgott & Bursztyn (1967). The efficacy and affinity of these agonists are affected differently by structural modifications. Our results
R M Eglen et al.
Naunyn-Schmiedeberg's archives of pharmacology, 342(4), 394-399 (1990-10-01)
1. para-Fluoro-hexahydrosila-difenidol (p-F-HHSiD) has been proposed as an M3 selective antagonist. However, the M3 selectivity is variable in that it exhibits a high pA2 value for M3 muscarinic receptors in guinea-pig ileum but a low value at muscarinic receptors in
Zizhuo Su et al.
American journal of translational research, 12(7), 3964-3973 (2020-08-11)
Cyclophilin A (CyPA) plays an important role in the progression of atherosclerosis. Additionally, it has been reported that lysosomal function is markedly impaired in atherosclerosis induced by oxidized low-density lipoprotein (ox-LDL). As the CyPA degradation pathway remains to be elucidated
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