D0387
6,7-二甲基-5,6,7,8-四氢蝶呤 盐酸盐
≥95%
别名:
2-氨基-4-羟基-6,7-二甲基-5,6,7,8-四氢蝶啶, DMPH4
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关于此项目
经验公式（希尔记法）:
C8H13N5O · HCl
化学文摘社编号:
分子量:
231.68
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
≥95%
Form:
powder
InChI
1S/C8H13N5O.ClH/c1-3-4(2)11-6-5(10-3)7(14)13-8(9)12-6;/h3-4,10H,1-2H3,(H4,9,11,12,13,14);1H
SMILES string
Cl[H].CC1Nc2nc(N)nc(O)c2NC1C
InChI key
GIHYTRGUZVYCQX-UHFFFAOYSA-N
assay
≥95%
form
powder
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
合成的还原蝶呤辅因子，用于一氧化氮合成酶，还用于苯丙氨酸、酪氨酸以及色氨酸羟化酶；活性低于天然辅因子四氢生物蝶呤 (BH4)。
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
S Koizumi et al.
The Journal of antibiotics, 35(4), 458-462 (1982-04-01)
Phenylalanine hydroxylase was shown to be inhibited by oudenone and its derivatives in vitro. At a concentration of 2.3 x 10(-3) M, oudenone inhibited phenylalanine hydroxylase by 50%, and some of the oudenone derivatives showed more potent inhibition. The kinetic
C Unger et al.
Cancer research, 45(2), 616-618 (1985-02-01)
The O-alkyl cleavage enzyme is important for the metabolism of cytotoxic alkyl-lysophospholipids. We have developed a simple new method for the determination of the enzyme activity which is based on the formation of water-soluble phosphate during the enzyme reaction. This
I G Jennings et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(13), 5734-5738 (1991-07-01)
A monoclonal anti-idiotype antibody, NS7, previously shown to mimic the binding of the pterin cofactor of phenylalanine hydroxylase (phenylalanine 4-monooxygenase, EC 1.14.16.1) has been used to localize the cofactor binding site within the phenylalanine hydroxylase catalytic domain to a 27-amino-acid
Alon Volner et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 8(1-2), 121-128 (2002-12-03)
Phenylalanine hydroxylase (PAH) is a pterin-dependent non-heme metalloenzyme that catalyzes the oxidation of phenylalanine to tyrosine, which is the rate-limiting step in the catabolism of Phe. Chromobacterium violaceum phenylalanine hydroxylase (cPAH) has been prepared and its steady-state mechanism has been
H Nakata et al.
Journal of biochemistry, 90(2), 567-569 (1981-08-01)
A simple and rapid method for isolating tryptophan 5-monooxygenase [L-tryptophan, tetrahydropteridine:oxygen oxidoreductase (5-hydroxylating), EC 1.14.16.4] was reported. The method involves adsorption on calcium phosphate gel and affinity chromatography on agarose coupled with dimethyltetrahydropteridine. Tryptophan 5-monooxygenase was purified 1,100-fold from a
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