D4407
2-脱氧-D-半乳糖
98%
别名:
2-脱氧-D-水解乳糖
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关于此项目
经验公式（希尔记法）:
C6H12O5
化学文摘社编号:
分子量:
164.16
UNSPSC Code:
12352201
NACRES:
NA.22
PubChem Substance ID:
EC Number:
217-765-3
Beilstein/REAXYS Number:
1723333
MDL number:
InChI key
PMMURAAUARKVCB-DUVQVXGLSA-N
InChI
1S/C6H12O5/c7-2-4-6(10)3(8)1-5(9)11-4/h3-10H,1-2H2/t3-,4-,5?,6-/m1/s1
SMILES string
OC[C@H]1OC(O)C[C@@H](O)[C@H]1O
assay
98%
form
powder
optical activity
[α]20/D +59.7°, c = 2 in H2O
color
white to off-white
mp
107 - 110 °C ((225 - 230 °F))
Quality Level
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General description
2-Deoxy-D-galactose is a glucose analog that shows a wide range of biological activities such as inhibition of glycolysis and thereby tumor growth, interference with the biosynthetic processing of glycoproteins, antiviral activity, and hepatotoxicity. It is being extensively studied as trapping agents for phosphate and uridylate in mammalian cells due to its ability to interfere in the phosphate and nucleotide metabolism.
Application
- FUT1-mediated terminal fucosylation acts as a new target to attenuate renal fibrosis.: This research investigates the role of 2-deoxy-D-galactose in modulating terminal fucosylation processes, revealing potential therapeutic pathways for treating renal fibrosis and enhancing the understanding of kidney disease mechanisms (Luo et al., 2023).
- 2-D-gal Targets Terminal Fucosylation to Inhibit T-cell Response in a Mouse Skin Transplant Model.: Highlights the immunomodulatory potential of 2-deoxy-D-galactose in transplant medicine, showing how it can inhibit T-cell responses and contribute to the success of skin grafts, pointing towards new immunosuppressive treatments (Mao et al., 2023).
- Inhibition of Aberrant α(1,2)-Fucosylation at Ocular Surface Ameliorates Dry Eye Disease.: Explores the therapeutic effects of 2-deoxy-D-galactose in treating dry eye disease by modulating specific fucosylation pathways, potentially opening new avenues for ocular surface treatment strategies (Yoon et al., 2021).
Other Notes
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
S P Rose et al.
Behavioral and neural biology, 48(2), 246-258 (1987-09-01)
When day-old chicks are trained on a passive avoidance task there is enhanced synthesis of glycoproteins. Bilateral intracerebral injections of 20 mumole of 2-deoxygalactose (2-D-gal), administered just before and just after training on the task, produce amnesia for the avoidance.
The Trapping of Uridine Phosphates by d-Galactosamine, d-Glucosamine, and 2-Deoxy-d-galactose: A Study on the Mechanism of Galactosamine Hepatitis
Keppler, Dietrich OR and Rudigier, J
European Journal of Biochemistry, 17(2), 246-253 (1970)
Raphaël Dutoit et al.
Nucleic acids research, 38(19), e183-e183 (2010-08-13)
Diverse tools are available for performing genetic modifications of microorganisms. However, new methods still need to be developed for performing precise genomic engineering without introducing any undesirable side-alteration. Indeed for functional analyses of genomic elements, as well as for some
Effects of glucose analogues (2-deoxy-D-glucose, 2-deoxy-D-galactose) on experimental tumors
Laszlo, John and Humphreys, Stewart R and Goldin, Abraham
Journal of the National Cancer Institute, 24(2), 267-281 (1960)
Yunrong Chai et al.
mBio, 3(4), e00184-e00112 (2012-08-16)
Galactose is a common monosaccharide that can be utilized by all living organisms via the activities of three main enzymes that make up the Leloir pathway: GalK, GalT, and GalE. In Bacillus subtilis, the absence of GalE causes sensitivity to
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