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E004

3-羟甲基-β-咔啉

别名:

3-HMC

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关于此项目

经验公式（希尔记法）:
C12H10N2O
化学文摘社编号:
65474-79-5
分子量:
198.22
NACRES:
NA.22
PubChem Substance ID:
329798936
UNSPSC Code:
12352100
MDL number:
MFCD00055074
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form

solid

Quality Level

200

mp

215-219 °C

SMILES string

OCc1cc2c(cn1)[nH]c3ccccc23

InChI

1S/C12H10N2O/c15-7-8-5-10-9-3-1-2-4-11(9)14-12(10)6-13-8/h1-6,14-15H,7H2

InChI key

CPBYHTDUBNSBQM-UHFFFAOYSA-N

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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3-hydroxymethyl-beta-carboline antagonizes some pharmacologic actions of diazepam.
P Skolinick et al.
European journal of pharmacology, 69(4), 525-527 (1981-02-19)
W B Mendelson et al.
Science (New York, N.Y.), 219(4583), 414-416 (1983-01-28)
The benzodiazepine receptor antagonist 3-hydroxymethyl-beta-carboline, which blocks several of the pharmacological actions of benzodiazepines, induces a dose-dependent increase in sleep latency in the rat. Furthermore, at a low dose that by itself does not affect sleep, 3-hydroxymethyl-beta-carboline blocks sleep induction
Do benzodiazepine receptors play a role in sleep regulation? Studies with the benzodiazepine antagonist, 3-hydroxymethyl-beta-carboline (3-HMC).
W B Mendelson et al.
Progress in clinical and biological research, 90, 253-261 (1982-01-01)
B Krespan et al.
Brain research, 295(2), 265-274 (1984-03-19)
The actions of the benzodiazepine (BDZ) antagonists 3-hydroxymethyl-beta-carboline (3-HMC), Ro 14-7437 and Ro 15-1788 were tested on single cell activity of rat hypothalamic neurons in tissue cultures and on membrane properties of CA1 hippocampal pyramidal neurons in transverse slices. In
N Naughton et al.
Life sciences, 36(23), 2239-2245 (1985-06-10)
It is reported that benzodiazepines such as diazepam will stimulate the opiate receptor system and that B-carboline drugs, which are benzodiazepine antagonists, may interact with opiate receptors directly. The ability of 3-hydroxymethyl-B-carboline (3-HMC) to antagonize several parameters of fentanyl anesthesia
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