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文件

G10105

18β-甘草次酸

Name: 18β-甘草次酸
Brand: ALDRICH

97%

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别名:

乌拉尔酸, 亚葡萄糖酸, 甘草次酸

经验公式（希尔记法）:

C₃₀H₄₆O₄

CAS号:

471-53-4

分子量:

470.68

Beilstein:

2229654

EC 号:

207-444-6

MDL编号:

MFCD00003706

PubChem化学物质编号:

24895033

NACRES:

NA.22

质量水平

100

检测方案

97%

旋光性

[α]22/D +170.0°, c = 1 in chloroform

mp

292-295 °C (lit.)

SMILES string

CC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]34C)C(O)=O

InChI

1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1

InChI key

MPDGHEJMBKOTSU-YKLVYJNSSA-N

Gene Information

human ... HSD11B1(3290) , HSD11B2(3291)
rat ... Hsd11b1(25116) , Hsd11b2(25117)

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一般描述

18 & # 946；甘草次酸是在光果甘草甘草根中发现的五环三萜类化合物。它是甘草甜素和甘草酸的主要代谢产物。

应用

该产品可用作制备18 & # 946；-甘草次酸衍生物，这种化合物显示抗炎和抗氧化特性。

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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T1503

货号

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A robust screening method for dietary agents that activate tumour-suppressor microRNAs.

Hagiwara K, et al.

Scientific Reports, 5 (2015)

Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases.

Igor Beseda et al.

Bioorganic & medicinal chemistry, 18(1), 433-454 (2009-11-17)

The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11beta-hydroxysteroid dehydrogenase (11beta-HSD) was investigated. Novel compounds with modifications at positions C-3, C-11 and C-29 of the GA skeleton were prepared. Single crystal X-ray diffraction data of selected substances are reported

18?-Glycyrrhetinic acid interaction with bovine serum albumin.

Zhou N, et al.

Journal of Photochemistry and Photobiology A: Chemistry, 185(2), 271-276 (2007)

Synthesis of new glycyrrhetinic acid derived ring A azepanone, 29-urea and 29-hydroxamic acid derivatives as selective 11β-hydroxysteroid dehydrogenase 2 inhibitors.

Rawindra Gaware et al.

Bioorganic & medicinal chemistry, 19(6), 1866-1880 (2011-03-08)

Glycyrrhetinic acid, the metabolite of the natural product glycyrrhizin, is a well known nonselective inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 and type 2. Whereas inhibition of 11β-HSD1 is currently under consideration for treatment of metabolic diseases, such as obesity

New novobiocin analogues as antiproliferative agents in breast cancer cells and potential inhibitors of heat shock protein 90.

Gaëlle Le Bras et al.

Journal of medicinal chemistry, 50(24), 6189-6200 (2007-11-06)

Selective hsp90 inhibitors simultaneously destabilize and deplete key signaling proteins involved in cell proliferation and survival, angiogenesis, and metastasis. Investigation of novobiocin analogues lacking the noviose moiety as novel inhibitors of hsp90 was carried out. A novel series of 3-aminocoumarin

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