H4530
7-羟基黄酮
≥98%
别名:
7-羟基-2-苯基-4-4H-1-苯并吡喃-4-酮, NSC 94258
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关于此项目
经验公式（希尔记法）:
C15H10O3
化学文摘社编号:
分子量:
238.24
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
229-705-3
MDL number:
产品名称
7-羟基黄酮, ≥98%
InChI key
MQGPSCMMNJKMHQ-UHFFFAOYSA-N
InChI
1S/C15H10O3/c16-11-6-7-12-13(17)9-14(18-15(12)8-11)10-4-2-1-3-5-10/h1-9,16H
SMILES string
Oc1ccc2C(=O)C=C(Oc2c1)c3ccccc3
assay
≥98%
mp
245-247 °C (lit.)
Gene Information
mouse ... Hexa(15211)
rat ... Ar(24208), Gabra2(29706)
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Application
作为如下过程的反应物：
- 在 O-糖基化反应中作为具有生物学价值的受体
- 参与合成完全磷酸化的黄酮类化合物，用作胰腺胆固醇酯酶抑制剂
- 用于碳酸二甲酯的 O-甲基化
- 通过多亚甲基链连接，合成 α1-肾上腺素受体拮抗剂
- 参与 Baylis-Hillman 反应
- 参与相转移催化的糖基化反应，合成糖基化的类黄酮
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
R Le Lain et al.
Journal of enzyme inhibition, 16(1), 35-45 (2001-08-11)
In a screening programme for inhibitors of human testis 17beta-hydroxysteroid dehydrogenase (17beta-HSD type 3), as potential agents for the treatment of hormone-dependent prostatic cancer, we have used crude human testis microsomal 17beta-hydroxysteroid dehydrogenase as a convenient source of the enzyme.
Opa Vajragupta et al.
Bioorganic & medicinal chemistry, 11(10), 2329-2337 (2003-04-26)
Manganese was incorporated in the structure of the selected antioxidants to mimic the superoxide dismutase (SOD) and to increase radical scavenging ability. Five manganese complexes (1-5) showed potent SOD activity in vitro with IC(50) of 1.18-1.84 microM and action against
Shun-Fa Yang et al.
Archives of oral biology, 53(3), 287-294 (2007-10-16)
Oral squamous cell carcinoma (OSCC) is one of the most common head and neck cancers with a poor prognosis due to frequent lymph node metastasis and local invasion. A growing number of in vitro studies have been conducted on the
J Thomas Sanderson et al.
Toxicological sciences : an official journal of the Society of Toxicology, 82(1), 70-79 (2004-08-21)
Flavonoids and related structures (e.g., flavones, isoflavones, flavanones, catechins) exert various biological effects, including anticarcinogenic, antioxidant and (anti-)estrogenic effects, and modulation of sex hormone homeostasis. A key enzyme in the synthesis of estrogens from androgens is aromatase (cytochrome P450 19;
T K Vinh et al.
Journal of enzyme inhibition, 16(5), 417-424 (2002-03-28)
A series of 4-aryl substituted 7-hydroxy-flavones were prepared using the three-step Baker-Venkataraman synthesis in good overall yields. The flavones were all evaluated in vitro for inhibitory activity against aromatase (P450AROM, CYP19), using human placental microsomes, and for inhibitory activity against
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