I5605
吲哚啉
ReagentPlus®, 99%
别名:
2,3-二氢吲哚, 吲哚啉
质量水平
产品线
ReagentPlus®
方案
99%
表单
liquid
折射率
n20/D 1.592 (lit.)
沸点
220-221 °C (lit.)
密度
1.063 g/mL at 25 °C (lit.)
SMILES字符串
C1Cc2ccccc2N1
InChI
1S/C8H9N/c1-2-4-8-7(3-1)5-6-9-8/h1-4,9H,5-6H2
InChI key
LPAGFVYQRIESJQ-UHFFFAOYSA-N
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应用
用作制备以下产品的反应物：
- NOD1 诱导的核因子-κB 活化抑制剂
- 1-磷酸鞘氨醇 4 (S1P4) 受体拮抗剂
- 细胞毒性细胞周期抑制剂
- 2-氨基吡啶类
- 用于蛋白激酶 C (PKC) 成像的 PET 试剂
- 治疗糖尿病高血糖症的钠依赖性葡萄糖协同转运蛋白 2 (SGLT2) 抑制剂
- α4β2-烟碱乙酰胆碱受体选择性部分激动剂
- mGlu4 阳性变构调节剂
- 细菌生物膜抑制剂
- 血清素 5-HT6 受体拮抗剂
法律信息
ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
199.4 °F - closed cup
闪点(°C)
93 °C - closed cup
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Matej Baláž et al.
Molecules (Basel, Switzerland), 24(18) (2019-09-22)
Performing solution-phase oximation reactions with hydroxylamine hydrochloride (NH2OH·HCl) carries significant risk, especially in aqueous solutions. In the present study, four N-substituted indole-3-carboxaldehyde oximes were prepared from the corresponding aldehydes by solvent-free reaction with NH2OH·HCl and a base (NaOH or Na2CO3)
Jan Michael Schuller et al.
Journal of molecular biology, 422(1), 87-99 (2012-06-12)
Fungal indole prenyltransferases (PTs) typically act on specific substrates, and they are able to prenylate their target compounds with remarkably high regio- and stereoselectivity. Similar to several indole PTs characterized to date, the cyclic dipeptide N-prenyltransferase (CdpNPT) is able to
Shaolin Zhu et al.
Journal of the American Chemical Society, 134(26), 10815-10818 (2012-06-22)
An enantioselective arylation-cyclization cascade has been accomplished using a combination of diaryliodonium salts and asymmetric copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction of pyrroloindolines, an important alkaloid structural motif that is commonly found
Fengtao Zhou et al.
Journal of the American Chemical Society, 134(35), 14326-14329 (2012-08-24)
The first highly enantioselective copper-catalyzed intramolecular Ullmann C-N coupling reaction has been developed. The asymmetric desymmetrization of 1,3-bis(2-iodoaryl)propan-2-amines catalyzed by CuI/(R)-BINOL-derived ligands led to the enantioselective formation of indolines in high yields and excellent enantiomeric excesses. This method was also
François Brucelle et al.
Organic letters, 14(12), 3048-3051 (2012-06-01)
A simple approach to prepare indolines and benzopyrrolizidinones from ortho-azidoallylbenzenes via a tandem radical addition/cyclization is described. The use of triethylborane to initiate and sustain the process provides the best results. Indolines are easily converted into the corresponding indoles by
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