K6625
2-酮己酸 钠盐
97.0-103.0%
别名:
α-氧代己酸 钠盐, 2-氧己酸 钠盐
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关于此项目
线性分子式:
C6H9O3Na
化学文摘社编号:
分子量:
152.12
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
97.0-103.0%
Form:
powder
Quality Level
InChI
1S/C6H10O3.Na/c1-2-3-4-5(7)6(8)9;/h2-4H2,1H3,(H,8,9);/q;+1/p-1
SMILES string
[Na].CCCCC(=O)C(O)=O
InChI key
WDCARDDLMCHULC-UHFFFAOYSA-M
assay
97.0-103.0%
form
powder
mp
240 °C (dec.) (lit.)
storage temp.
2-8°C
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
S Lenzen et al.
The Journal of biological chemistry, 260(23), 12629-12634 (1985-10-15)
High aminotransferase activities catalyzing the reactions between L-glutamate and L-glutamine and the aliphatic ketomonocarboxylic acids 2-ketoisocaproate, 2-ketocaproate, and 2-ketoisovalerate were observed in pancreatic B-cell mitochondria. While maximal rates of transamination with L-glutamate were observed in the presence of micromolar concentrations
S Lenzen et al.
The Journal of biological chemistry, 257(12), 6631-6633 (1982-06-25)
2-Ketocaproate and 2-ketoisocaproate were equally potent insulin secretagogues. The insulin secretory potency of L-leucine was less than half of that of the keto acids and L-norleucine did not induce any insulin release by isolated islets and by the perfused pancreas
M U Javed et al.
Journal of enzyme inhibition, 10(3), 187-193 (1996-01-01)
An LDH isoenzyme was purified to homogeneity from uromastix testes and its inhibition spectrum towards known LDH isoenzyme inhibitors studied. Platinum compounds inhibited the enzyme in the forward reaction (pyruvate-->lactate) only, n-hexanediol and colchicine showed no inhibition and gossypol acetic
S A Metz
The Journal of pharmacology and experimental therapeutics, 238(3), 809-818 (1986-09-01)
Activation of an islet phospholipase A2 may contribute to glucose-induced insulin release. In order to simulate the accumulation of the resultant hydrolytic products (arachidonic acid, AA; its lipoxygenase-derived oxygenation product 12-hydroxyeicosatetraenoic acid; and lysophospholipids) without many of the other concomitants
W J Malaisse
Diabete & metabolisme, 9(4), 313-320 (1983-12-01)
Insulin release evoked by nutrient secretagogues invariably coincides with an increase in the catabolism of exogenous and/or endogenous nutrients in pancreatic islet cells, resulting in an increased generation rate of reducing equivalents and ATP, and an increase in O2 consumption.
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