4-Formylbenzene diazonium hexafluorophosphate

• Tyrosine-selective bioconjugation reagent for the incorporation of a bioorthogonal aldehyde into peptides, proteins, antibodies or cell surfaces.
• The aldehyde can then be reacted with a variety of bioconjugation, labeling or detection reagents containing hydrazine/hydrazide or oxyamine functionalities.
• FBDP is a novel development in the field of Tyr bioconjugation as it is bench-stable as opposed to prevoius diazonium reagents that require in situ preparation.
• FBDP has been shown to modify small molecules, peptides, proteins and living cell surface proteins in high yields.
• The labeling proceeds quickly with common reaction times of 30 min at room temperature at pH 7-8 (slightly higher yield and selectivity seen at pH 8).

Reference: Formylbenzene Diazonium Hexafluorophosphate Reagent for Tyrosine-selective Modification of Proteins and the Introduction of a Bioorthogonal Aldehyde Gavrilyuk, J.; Ban, H.; Nagano, M.; Hakamata, W.; Barbas III, C.F. Bioconjugate Chemistry (2012) 23: 2321-2328 DOI: 10.1021/bc300410p

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