M2627
5-甲基吲哚-2-甲酸
别名:
NSC 88873
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关于此项目
经验公式（希尔记法）:
C10H9NO2
化学文摘社编号:
分子量:
175.18
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
InChI
1S/C10H9NO2/c1-6-2-3-8-7(4-6)5-9(11-8)10(12)13/h2-5,11H,1H3,(H,12,13)
SMILES string
Cc1ccc2[nH]c(cc2c1)C(O)=O
InChI key
DAITVOCMWPNFTL-UHFFFAOYSA-N
Application
reactant in preparation of Pin1 inhibitors as potential antitumor agents
reactant in preparation of non-imidazole human histamine H4 receptor antagonists
reactant in preparation of non-imidazole human histamine H4 receptor antagonists
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Andrew Potter et al.
Bioorganic & medicinal chemistry letters, 20(22), 6483-6488 (2010-10-12)
Pin1 is an emerging oncology target strongly implicated in Ras and ErbB2-mediated tumourigenesis. Pin1 isomerizes bonds linking phospho-serine/threonine moieties to proline enabling it to play a key role in proline-directed kinase signalling. Here we report a novel series of Pin1
Jill A Jablonowski et al.
Journal of medicinal chemistry, 46(19), 3957-3960 (2003-09-05)
Following the discovery of the human histamine H4 receptor, a high throughput screen of our corporate compound collection identified compound 6 as a potential lead. Investigation of the SAR resulted in the discovery of novel compounds 10e and 10l, which
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