N8105
3-哌啶甲酰胺
95%
别名:
3-Carbamoylpiperidine, 3-Piperidinecarboxamide
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关于此项目
经验公式（希尔记法）:
C6H12N2O
化学文摘社编号:
分子量:
128.17
UNSPSC Code:
12352100
PubChem Substance ID:
EC Number:
223-962-5
MDL number:
assay
95%
form
solid
mp
103-106 °C (lit.)
SMILES string
NC(=O)C1CCCNC1
InChI
1S/C6H12N2O/c7-6(9)5-2-1-3-8-4-5/h5,8H,1-4H2,(H2,7,9)
InChI key
BVOCPVIXARZNQN-UHFFFAOYSA-N
Application
Reactant for synthesis of:
- DPP-4 inhibitors
- IKKβ inhibitors
- Spiroimidazolidinone NPC1L1 inhibitors
- Sulfamides
- Phosphodiesterase 5 inhibtors
- Anti-HIV agents
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
S Puglisi-Allegra et al.
Psychopharmacology, 70(3), 287-290 (1980-01-01)
An inhibitor of GABA-T (sodium n-dipropylacetate), a GABA agonist (muscimol hydrobromide) and an inhibitor of GABA uptake (R,S) nipecotic acid amide were administered to DBA/2 isolated aggressive mice throughout three successive daily experimental sessions. Aggressive responses, measured by an automated
Relationships between the chemical constitution of carbamoylpiperidines and related compounds, and their inhibition of ADP-induced human blood platelet aggregation.
R P Quintana et al.
Thrombosis research, 22(5-6), 665-680 (1981-06-01)
Nipecotic and iso-nipecotic amides as potent and selective somatostatin subtype-2 receptor agonists.
C Zhou et al.
Bioorganic & medicinal chemistry letters, 11(3), 415-417 (2001-02-24)
N-Substituted nipecotic and iso-nipecotic amides of beta-methylTrpLys tert-butyl ester were found to be novel, selective and potent agonists of the somatostatin subtype-2 receptor in vitro. For example iso-nipecotic amide 8a showed high hsst2 binding affinity (Ki = 0.5 nM) and
A Depaulis et al.
Psychopharmacology, 83(4), 367-372 (1984-01-01)
When GABA-potentiating compounds were administered IP to rats with prior experience of mouse-killing behaviour, a reduction of killing was observed with gamma-vinyl GABA (200 and 400 mg/kg) and nipecotic acid amide (400 mg/kg), while no significant effect was noted following
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