P1101
D-青霉胺二硫化物
97%, cell analysis
别名:
3,3′-二硫代双(2-氨基-3-甲基丁酸), S,S′-二(D-青霉胺), 二硫青霉胺
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关于此项目
线性分子式:
[-SC(CH3)2CH(NH2)CO2H]2
化学文摘社编号:
分子量:
296.41
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
244-107-2
MDL number:
Beilstein/REAXYS Number:
4461521
产品名称
D-青霉胺二硫化物, 97%
InChI
1S/C10H20N2O4S2/c1-9(2,5(11)7(13)14)17-18-10(3,4)6(12)8(15)16/h5-6H,11-12H2,1-4H3,(H,13,14)(H,15,16)/t5-,6-/m0/s1
InChI key
POYPKGFSZHXASD-WDSKDSINSA-N
SMILES string
CC(C)(SSC(C)(C)[C@@H](N)C(O)=O)[C@@H](N)C(O)=O
assay
97%
form
powder or crystals
optical activity
[α]25/D −75°, c = 1 in 1 M NaOH
reaction suitability
reaction type: solution phase peptide synthesis
color
white
mp
204 °C (dec.) (lit.)
application(s)
cell analysis
Quality Level
Application
Used in pharmacological studies of:
- Molecules dermatomyositis activity
- Antimelanoma activity of apoptogenic carbonyl scavengers
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
K K Millis et al.
Biochimica et biophysica acta, 1055(1), 10-18 (1990-10-15)
The oxidation/reduction chemistry of penicillamine in human erythrocytes was characterized directly in intact erythrocytes by 1H-NMR spectroscopy. Spectra were measured by the Carr-Purcell-Meiboom-Gill pulse sequence to selectively eliminate interfering resonances from hemoglobin and membrane protons and from the intracellular water.
Y J Yang et al.
Occupational and environmental medicine, 51(4), 267-270 (1994-04-01)
Four workers chronically exposed to elemental mental mercury in a lampsocket manufacturing factory were studied. The clinical manifestations were severe in one, mild in another, and suspicious in the remaining two. Correlation between severity of clinical features and increased urinary
J C Crawhall
Clinical and investigative medicine. Medecine clinique et experimentale, 7(1), 31-34 (1984-01-01)
Penicillamine disulfides have been analysed by automatic amino acid analysis. Because the free thiol reacts poorly with ninhydrin, other detection methods are preferred, particularly high pressure liquid chromatography using an electrochemical detector or gas chromatography with a flame ionization detector.
T F Yu et al.
The Journal of rheumatology, 11(4), 467-470 (1984-08-01)
Four patients with recurrent cystine stones and 5 with rheumatoid arthritis (RA) were studied. After a single dose of D-penicillamine to cystinuric patients, cystine excretion decreased considerably. Cysteine-penicillamine mixed disulfide (CSSP) and penicillamine disulfide (PSSP) metabolites appeared within 1-2 h
J K Nicholson et al.
Drug metabolism and drug interactions, 6(3-4), 439-446 (1988-01-01)
Preliminary studies on the use of high resolution 1H-NMR spectroscopy for the detection of the thiol drug penicillamine and its metabolites in human urine are described. The technique is rapid, simple and requires minimal sample pretreatment. Application of NMR to
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