InChI
1S/C40H60F4N2O17/c41-32-31-33(42)39(44)40(38(32)43)63-37(50)4-7-51-9-11-53-13-15-55-17-19-57-21-23-59-25-27-61-29-30-62-28-26-60-24-22-58-20-18-56-16-14-54-12-10-52-8-5-45-34(47)3-6-46-35(48)1-2-36(46)49/h1-2,31H,3-30H2,(H,45,47)
InChI key
TYRMHYMPAXBKTH-UHFFFAOYSA-N
SMILES string
O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)OC2=C(C(F)=CC(F)=C2F)F
assay
>90%
form
solid or viscous liquid
reaction suitability
reactivity: thiol reactive, reagent type: cross-linking reagent
reactivity: amine reactive
polymer architecture
shape: linear
functionality: heterobifunctional
shipped in
ambient
storage temp.
−20°C
Features and Benefits
MAL-dPEG®12-TFP ester is a heterobifunctional, linear crosslinking reagent containing a maleimide group on one end of the single molecular weight dPEG® spacer arm and an amine-reactive active ester on the other end. The maleimide group reacts readily and specifically with free sulfhydryl groups in aqueous media at pH 6.5-7.5. 2,3,5,6-tetrafluorophenyl (TFP) ester ester is used widely in reactions with primary amines. The TFP-amine reactions can be carried out in aqueous or organic solvent. The dPEG® spacer is hydrophilic and non-immunogenic. Because it is a single molecular weight product, it gives the user precise spatial control. The dPEG® spacer also improves water solubility, decreases immunogenicity, and increases the hydrodynamic volume of the conjugate. The increased hydrodynamic volume results in longer serum half-life in vivo.
Legal Information
Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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